Inhibition of Beta-Amyloid Fibrillation by Luminescent Iridium(III) Complex Probes

We report herein the application of kinetically inert luminescent iridium(III) complexes as dual inhibitors and probes of beta-amyloid fibrillogenesis. These iridium(III) complexes inhibited Aβ 1–40 peptide aggregation in vitro and protected against Aβ-induced cytotoxicity in neuronal cells. Further...

Full description

Saved in:
Bibliographic Details
Published inScientific reports Vol. 5; no. 1; p. 14619
Main Authors Lu, Lihua, Zhong, Hai-Jing, Wang, Modi, Ho, See-Lok, Li, Hung-Wing, Leung, Chung-Hang, Ma, Dik-Lung
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 30.09.2015
Nature Publishing Group
Subjects
140/131
639/638/263
639/638/92
Alzheimer's disease
Amyloid beta-Peptides - chemistry
Amyloid beta-Peptides - metabolism
Animals
Cell Line, Tumor
Cell Survival
Cytotoxicity
Fibrillation
Fibrillogenesis
Humanities and Social Sciences
Humans
Iridium
Iridium - chemistry
Iridium - pharmacology
Labeling
Ligands
Luminescent Agents
Mice
Microscopy
Molecular Structure
multidisciplinary
Neuroblastoma
Neurons - metabolism
Neurons - pathology
Peptides
Probes
Protein Aggregates - drug effects
Protein Aggregation, Pathological - drug therapy
Protein Aggregation, Pathological - metabolism
Science
β-Amyloid
Online AccessGet full text

Cover

More Information
Summary:We report herein the application of kinetically inert luminescent iridium(III) complexes as dual inhibitors and probes of beta-amyloid fibrillogenesis. These iridium(III) complexes inhibited Aβ 1–40 peptide aggregation in vitro and protected against Aβ-induced cytotoxicity in neuronal cells. Furthermore, the complexes differentiated between the aggregated and unaggregated forms of Aβ 1–40 peptide on the basis of their emission response.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
These authors contributed equally to this work.
ISSN:2045-2322
2045-2322
DOI:10.1038/srep14619