Chondroitin sulfates and their binding molecules in the central nervous system

• Published in: Glycoconjugate journal Vol. 34; no. 3; pp. 363 - 376
• Main Authors: Djerbal, L, Lortat-Jacob, H, Kwok, JCF
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.06.2017; Springer Nature B.V; Springer Verlag
• Subjects: Animals; Binding sites; Biochemistry; Biochemistry, Molecular Biology; Biomedical and Life Sciences; Carbohydrate Conformation; Carrier Proteins - chemistry; Carrier Proteins - metabolism; Central nervous system; Central Nervous System - chemistry; Central Nervous System - metabolism; Chondroitin sulfate; Chondroitin Sulfates - chemistry; Chondroitin Sulfates - metabolism; Cognitive ability; Cytokines - chemistry; Cytokines - metabolism; Extracellular Matrix - chemistry; Extracellular Matrix - metabolism; Extracellular Matrix Proteins - chemistry; Extracellular Matrix Proteins - metabolism; Growth factors; Humans; Intercellular Signaling Peptides and Proteins - chemistry; Intercellular Signaling Peptides and Proteins - metabolism; Life Sciences; Molecules; Nervous system; Neural Cell Adhesion Molecules - chemistry; Neural Cell Adhesion Molecules - metabolism; Neurodegenerative diseases; Neurons - chemistry; Neurons - metabolism; Pathology; Protein Binding; Proteoglycans - chemistry; Proteoglycans - metabolism; Receptor-Like Protein Tyrosine Phosphatases - chemistry; Receptor-Like Protein Tyrosine Phosphatases - metabolism; Review; Reviews; Structural Biology; Proteoglycans; Glycosaminoglycans; Central nervous system; Plasticity; Chondroitin sulfate; Perineuronal nets; Protein-glycosaminoglycan interactions
• ISSN: 0282-0080; 1573-4986; 1573-4986
• DOI: 10.1007/s10719-017-9761-z

Chondroitin sulfate (CS) is the most abundant glycosaminoglycan (GAG) in the central nervous system (CNS) matrix. Its sulfation and epimerization patterns give rise to different forms of CS, which enables it to interact specifically and with a significant affinity with various signalling molecules in the matrix including growth factors, receptors and guidance molecules. These interactions control numerous biological and pathological processes, during development and in adulthood. In this review, we describe the specific interactions of different families of proteins involved in various physiological and cognitive mechanisms with CSs in CNS matrix. A better understanding of these interactions could promote a development of inhibitors to treat neurodegenerative diseases.