Cloning, characterization, and functional expression of cDNAs encoding glucose transporter proteins from the human parasite Schistosoma mansoni

• Published in: The Journal of biological chemistry Vol. 269; no. 6; pp. 4247 - 4253
• Main Authors: SKELLY, P. J, JUNG WOO KIM, CUNNINGHAM, J, SHOEMAKER, C. B
• Format: Journal Article
• Language: English
• Published: Bethesda, MD American Society for Biochemistry and Molecular Biology 11.02.1994
• Subjects: Analytical, structural and metabolic biochemistry; Animals; Base Sequence; Binding and carrier proteins; Biological and medical sciences; Biological Transport; Cloning, Molecular; Deoxyglucose - metabolism; DNA Primers - chemistry; DNA, Complementary - genetics; Female; Fundamental and applied biological sciences. Psychology; Gene Expression; Genes, Helminth; Male; Molecular Sequence Data; Monosaccharide Transport Proteins - chemistry; Monosaccharide Transport Proteins - genetics; Mutagenesis, Site-Directed; Proteins; Recombinant Proteins - metabolism; Restriction Mapping; RNA, Messenger - genetics; Schistosoma mansoni; Schistosoma mansoni - genetics; Sequence Alignment; Sequence Homology, Amino Acid; Structure-Activity Relationship; Schistosoma mansoni; Regulation(control); Substrate specificity; Helmintha; Plathelmintha; Glucose; Invertebrata; Molecular cloning; Carrier protein; Trematoda; Biological activity; Aminoacid sequence

The blood-dwelling adult form of the parasitic worm, Schistosoma mansoni, consumes prodigious quantities of host glucose following its transport across the tegument. Immunologic or pharmacologic targeting of the relevant transporter proteins might form the basis of a schistosome control strategy. He...