MiR-223-3p targeting SEPT6 promotes the biological behavior of prostate cancer

• Published in: Scientific reports Vol. 4; no. 1; p. 7546
• Main Authors: Wei, Yongbao, Yang, Jinrui, Yi, Lu, Wang, Yinhuai, Dong, Zhitao, Liu, Ziting, Ou-yang, Shifeng, Wu, Hongtao, Zhong, Zhaohui, Yin, Zhuo, Zhou, Keqin, Gao, Yunliang, Yan, Bin, Wang, Zhao
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 18.12.2014; Nature Publishing Group
• Subjects: 13; 13/109; 13/2; 38; 38/22; 38/39; 45; 45/22; 45/41; 631/67/68; 631/80/84/2336; Autoimmune diseases; Biological activity; Cell Line, Tumor; Chromosome 3; Gastric cancer; Gene Expression Regulation, Neoplastic - genetics; Genes; Humanities and Social Sciences; Humans; Kidney cancer; Male; MicroRNAs - genetics; miRNA; multidisciplinary; Pancreatic cancer; Prostate cancer; Prostatic Neoplasms - genetics; Rheumatoid arthritis; Science; Septins - genetics; Systemic lupus erythematosus; Up-Regulation - genetics; Urinary bladder
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/srep07546

MicroRNAs (miRNAs) present frequently altered expression in urologic cancers including prostate, bladder and kidney cancer. The altered expression of miR-223 has been reported in cancers and other diseases in recent researches. MiR-223 is up-regulated in systemic lupus erythematosus and rheumatoid arthritis. In neoplastic diseases, miR-223 is proved to be up-expressed in plasma or serum and cancer tissues compared with normal tissues in pancreatic cancer, gastric cancer, et al. However, whether altered expression of miR-223 is associated with prostate cancer (PCa) and what it is potential functions in PCa remained unveiled. In this study, we firstly found miR-223-3p were up-regulated in prostate cancer tissues and then we study functional role of miR-223-3p in PCa using DU145, PC3 and LNCaP cell lines. Our data suggested that miR-223-3p might target gene SEPT6 and promoted the biological behavior of prostate cancer. Notably, we found increasing SEPT6 expression might reverse the biological activity induced by miR-223-3p, which might be a potential therapeutic target for PCa.