Angiogenesis inhibition suppresses collagen arthritis

Neovascularization is observed in a spectrum of diseases such as solid tumors, diabetic retinopathy, and rheumatoid arthritis. It is also evident in rat collage-induced arthritis (CIA), an animal model with histologic, clinical, and radiographic manifestations resembling rheumatoid arthritis. To eva...

Full description

Saved in:
Bibliographic Details
Published inThe Journal of experimental medicine Vol. 175; no. 4; pp. 1135 - 1138
Main Authors PEACOCK, D. J, BANQUERIGO, M. L, BRAHN, E
Format Journal Article
LanguageEnglish
Published New York, NY Rockefeller University Press 01.04.1992
The Rockefeller University Press
Subjects
Animals
Arthritis - immunology
Arthritis - pathology
Biological and medical sciences
Collagen - immunology
Cyclohexanes
Diseases of the osteoarticular system
Hypersensitivity, Delayed - immunology
Inflammatory joint diseases
Medical sciences
Neovascularization, Pathologic
O-(Chloroacetylcarbamoyl)fumagillol
Rats
Rats, Inbred Strains
Sesquiterpenes - pharmacology
Animal model
Immunization
Pathogenesis
Suppression
Diseases of the osteoarticular system
Autoimmune disease
Inflammatory joint disease
Arthritis
Glycoproteins
Histology
Angiogenesis
Experimental disease
Collagen
Inhibitor
Inhibition
Neovascularization
Online AccessGet full text

Cover

More Information
Summary:Neovascularization is observed in a spectrum of diseases such as solid tumors, diabetic retinopathy, and rheumatoid arthritis. It is also evident in rat collage-induced arthritis (CIA), an animal model with histologic, clinical, and radiographic manifestations resembling rheumatoid arthritis. To evaluate the effects of angioinhibition in CIA, Louvain rats were immunized with type II collagen to induce arthritis and then administered an angiogenesis inhibitor, AGM-1470, in an attempt to either prevent arthritis or suppress established disease. Using clinical and radiographic criteria, AGM-1470 prevented CIA and significantly suppressed established disease without evidence of immunosuppression. Histologic sections from control ankle joints manifested pannus and neovascularization, which were absent in experimental animals. This is the first study to investigate this novel agent in an autoimmune disease, and additional evaluation of this promising compound in other diseases that are potentially angiogenesis dependent, such as rheumatoid arthritis, might be warranted.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0022-1007
1540-9538
DOI:10.1084/jem.175.4.1135