Prognostic Significance of Neutrophil to Lymphocyte Ratio, Lymphocyte to Monocyte Ratio, and Platelet to Lymphocyte Ratio in Patients with Nasopharyngeal Carcinoma

• Published in: BioMed research international Vol. 2017; no. 2017; pp. 1 - 6
• Main Authors: Cai, Yonglin, Ou, Ningjiang, Zhong, Weiming, Wu, Huihui, Li, Jun, Tang, Minzhong, Zheng, Yuming, Li, Haifeng, Lu, Aiying, Gao, Jianquan
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2017; Hindawi; Hindawi Limited
• Subjects: Adolescent; Adult; Aged; Angiogenesis; Blood Platelets; Cancer; Cancer therapies; Carcinoma; Cell growth; Chemotherapy; Child; Cytokines; Disease-Free Survival; Female; Hematology; Humans; Laboratories; Lymphocyte Count; Lymphocytes; Male; Medical prognosis; Metastasis; Middle Aged; Monocytes; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms - blood; Nasopharyngeal Neoplasms - mortality; Neutrophils; Patients; Platelet Count; Radiation therapy; Statistical analysis; Survival Rate; Tumor necrosis factor-TNF; Tumors; China
• ISSN: 2314-6133; 2314-6141
• DOI: 10.1155/2017/3047802

The peripheral blood neutrophil to lymphocyte ratio (NLR), lymphocyte to monocyte ratio (LMR), and platelet to lymphocyte ratio (PLR) have been reported to correlate with the prognosis of many malignancies. This study evaluated the prognostic value of pretreatment NLR, LMR, and PLR in nasopharyngeal carcinoma (NPC). A retrospective analysis of clinical and pathological data of 140 NPC patients without distant metastasis during initial treatment was conducted to identify correlations between NLR, LMR, and PLR and clinicopathological features, overall survival, and progression-free survival. Cox proportional hazard regression analysis was used to reveal the independent factors affecting the prognosis of NPC patients. NLR was associated with T staging, N staging, and overall clinical stage grouping of the NPC patients (P<0.05). NLR ≥ 2.28, LMR < 2.26, and PLR ≥ 174 were significantly associated with a relatively short overall survival (P<0.05). In addition, NLR ≥ 2.28 was significantly associated with a relatively short progression-free survival (P<0.05). Cox proportional hazard regression analysis showed that NLR was an independent prognostic factor in NPC. Pretreatment NLR, LMR, and PLR might be a useful complement to TNM staging in the prognostic assessment of NPC patients.