The Poor Performance of RSR′ Pattern on Electrocardiogram Lead V1 for Detection of Secundum Atrial Septal Defects in Children

• Published in: The Journal of pediatrics Vol. 162; no. 2; pp. 308 - 312
• Main Authors: Schiller, Ofer, MD, Greene, E. Anne, MD, Moak, Jeffrey P., MD, Gierdalski, Marcin, PharmD, PhD, Berul, Charles I., MD
• Format: Journal Article
• Language: English
• Published: United States Mosby, Inc 01.02.2013
• Subjects: Adolescent; Child; Child, Preschool; children; echocardiography; Electrocardiography; Female; Heart Septal Defects, Atrial - diagnosis; Humans; lead; Male; patients; Pediatrics; Predictive Value of Tests; Reproducibility of Results; Retrospective Studies; screening; ASD; RSR′ pattern in lead V1; RVH; Electrocardiogram; Atrial septal defect; ECG; Right ventricular hypertrophy; CHD; Congenital heart defects; RSR′-V1
• ISSN: 0022-3476; 1097-6833
• DOI: 10.1016/j.jpeds.2012.07.017

Objective To assess the accuracy of RSR′ patterns in lead V1 (RSR′-V1) in diagnosing atrial septal defects (ASDs) in children. Study design Children who underwent an electrocardiogram (ECG) during 2010 were divided into 2 ECG groups: RSR′-V1 and normal (no RSR′-V1). Children who underwent an echocardiogram during 2010 were also divided into an ASD group and a normal echocardiogram group. The 4 groups were matched in a 2 × 2 table format where the RSR′-V1 was the “test” and ASD was the “disease.” Sensitivity, specificity, positive/negative predictive values, and pre/post-test probabilities were calculated. Results There were 4658 ECG studies included in the analysis: 836 had RSR′-V1 and 3822 were normal without RSR′-V1. Of 4935 echocardiographic studies analyzed, 329 had an ASD and 4606 were normal; 1363 patients had both studies done during the study period. The ECG sensitivity for diagnosing an ASD was 36.1%, specificity was 80%, positive predictive value was 14.7%, and negative predictive value was 92.9% with an overall accuracy of 76.2%. Patients with ASD and RSR′-V1 were significantly older than patients with ASD and no RSR′-V1 pattern. Conclusion RSR′-V1 is a poor screening test for the detection of ASD. It should not change the clinical suspicion or the decision to obtain an echocardiogram. Older children without RSR′-V1 on ECG are unlikely to have an ASD.