Comparison of Two Different Segmentation Methods on Planar Lung Perfusion Scan with Reference to Quantitative Value on SPECT/CT

• Published in: Nuclear medicine and molecular imaging Vol. 51; no. 2; pp. 161 - 168
• Main Authors: Suh, Minseok, Kang, Yeon-koo, Ha, Seunggyun, Kim, Yong-il, Paeng, Jin Chul, Cheon, Gi Jeong, Park, Samina, Kim, Young Tae, Lee, Dong Soo, Kim, E. Edmund, Chung, June-Key
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.06.2017; Springer Nature B.V; 대한핵의학회
• Subjects: Cancer; Cardiology; Computation; Computed tomography; Correlation analysis; Imaging; Lobes; Lung cancer; Medicine; Medicine & Public Health; Methods; Nuclear Medicine; Oncology; Original; Original Article; Orthopedics; Patients; Photon emission; Predictions; Radiology; Reproducibility; Segmentation; Technetium; Tomography; 방사선과학; Lung function; Perfusion imaging; SPECT-CT; Lung cancer
• ISSN: 1869-3474; 1869-3482
• DOI: 10.1007/s13139-016-0448-3

Purpose Until now, there was no single standardized regional segmentation method of planar lung perfusion scan. We compared planar scan based two segmentation methods, which are frequently used in the Society of Nuclear Medicine, with reference to the lung perfusion single photon emission computed tomography (SPECT)/computed tomography (CT) derived values in lung cancer patients. Methods Fifty-five lung cancer patients (male:female, 37:18; age, 67.8 ± 10.7 years) were evaluated. The patients underwent planar scan and SPECT/CT after injection of technetium-99 m macroaggregated albumin (Tc-99 m-MAA). The % uptake and predicted postoperative percentage forced expiratory volume in 1 s (ppoFEV1%) derived from both posterior oblique (PO) and anterior posterior (AP) methods were compared with SPECT/CT derived parameters. Concordance analysis, paired comparison, reproducibility analysis and spearman correlation analysis were conducted. Results The % uptake derived from PO method showed higher concordance with SPECT/CT derived % uptake in every lobe compared to AP method. Both methods showed significantly different lobar distribution of % uptake compared to SPECT/CT. For the target region, ppoFEV1% measured from PO method showed higher concordance with SPECT/CT, but lower reproducibility compared to AP method. Preliminary data revealed that every method significantly correlated with actual postoperative FEV1%, with SPECT/CT showing the best correlation. Conclusion The PO method derived values showed better concordance with SPECT/CT compared to the AP method. Both PO and AP methods showed significantly different lobar distribution compared to SPECT/CT. In clinical practice such difference according to different methods and lobes should be considered for more accurate postoperative lung function prediction.