A prospective epidemiological study of new incident GISTs during two consecutive years in Rhône Alpes region: incidence and molecular distribution of GIST in a European region

• Published in: British journal of cancer Vol. 103; no. 2; pp. 165 - 170
• Main Authors: Cassier, P A, Ducimetière, F, Lurkin, A, Ranchère-Vince, D, Scoazec, J-Y, Bringuier, P-P, Decouvelaere, A-V, Méeus, P, Cellier, D, Blay, J-Y, Ray-Coquard, I
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 13.07.2010; Nature Publishing Group
• Subjects: 631/208/2489/144/68; 692/699/67/1504; 692/699/67/2324; Adult; Aged; Aged, 80 and over; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Cancer Research; Clinical Study; Drug Resistance; Epidemiology; Female; France - epidemiology; Gastroenterology. Liver. Pancreas. Abdomen; Gastrointestinal Stromal Tumors - epidemiology; Gastrointestinal Stromal Tumors - genetics; Humans; Incidence; Kinases; Male; Medical research; Medical sciences; Middle Aged; Molecular Medicine; Mutation; Oncology; Pathology; Patients; Prospective Studies; Receptor, Platelet-Derived Growth Factor alpha - genetics; Risk Assessment; Sarcoma; Sarcoma - epidemiology; Sarcoma - genetics; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Tumors; France; Rhône Alpes; Europe; PDGFRA; gastrointestinal stromal tumour (GIST); kinase mutations; incidence; KIT; Platelet derived growth factor receptor A; Enzyme; Transferases; Epidemiology; Incidence; Gastrointestinal stromal tumor; Prospective; Cancerology; Kinase; C-Onc gene; Distribution; Digestive diseases; Intestinal disease; Genetics; Mutation; Protooncogene
• ISSN: 0007-0920; 1532-1827
• DOI: 10.1038/sj.bjc.6605743

Background: Preliminary data indicate that the molecular epidemiology of localised gastrointestinal stromal tumour (GIST) may be different from that of advanced GIST. We sought to investigate the molecular epidemiology of sarcomas, including GIST, in the Rhone-Alpes region in France. Patients and methods: A prospective and exhaustive study in the Rhone-Alpes Region in France to assess the precise incidence of primary sarcomas with systematic centralised pathological review and molecular analysis was conducted for 2 consecutive years. Results: Among 760 patients with a confirmed diagnosis of sarcoma, 131 (17%) had a GIST. The majority of patients had gastric primaries (61%). Mutational analysis could be performed in 106 tumour samples (74%), and 71 (67%) had exon 11 mutations. PDGFRA mutations were found in 16% of cases, which is twice as high as previously reported for advanced GIST. Conclusion: Data indicate that PDGFRA mutations in localised GIST may be twice as high as what was previously reported in patients with advanced disease. This finding may have important consequences for patients offered adjuvant imatinib, although most of these tumours are in the low-risk group.