Precursors to pancreatic cancer

Infiltrating ductal adenocarcinoma of the pancreas is believed to arise from morphologically distinct noninvasive precursor lesions. These precursors include the intraductal papillary mucinous neoplasm, the mucinous cystic neoplasm, and pancreatic intraepithelial neoplasia. Intraductal papillary muc...

Full description

Saved in:
Bibliographic Details
Published inGastroenterology clinics of North America Vol. 36; no. 4; p. 831
Main Authors Hruban, Ralph H, Maitra, Anirban, Kern, Scott E, Goggins, Michael
Format Journal Article
LanguageEnglish
Published United States 01.12.2007
Subjects
Humans
Pancreas - pathology
Pancreatic Neoplasms - pathology
Precancerous Conditions
Risk Factors
Online AccessGet more information

Cover

More Information
Summary:Infiltrating ductal adenocarcinoma of the pancreas is believed to arise from morphologically distinct noninvasive precursor lesions. These precursors include the intraductal papillary mucinous neoplasm, the mucinous cystic neoplasm, and pancreatic intraepithelial neoplasia. Intraductal papillary mucinous neoplasms are grossly visible mucin-producing epithelial neoplasms that arise in the main pancreatic duct or one of its branches. The cysts of mucinous cystic neoplasms do not communicate with the major pancreatic ducts, and these neoplasms are characterized by a distinct ovarian-type stroma. Pancreatic intraepithelial neoplasia is a microscopic lesion. This article focuses on the clinical significance of these three important precursor lesions, with emphasis on their clinical manifestations, detection, and treatment.
ISSN:0889-8553
DOI:10.1016/j.gtc.2007.08.012