Terahertz reflectometry imaging for low and high grade gliomas

Gross total resection (GTR) of glioma is critical for improving the survival rate of glioma patients. One of the greatest challenges for achieving GTR is the difficulty in discriminating low grade tumor or peritumor regions that have an intact blood brain barrier (BBB) from normal brain tissues and...

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Published inScientific reports Vol. 6; no. 1; p. 36040
Main Authors Ji, Young Bin, Oh, Seung Jae, Kang, Seok-Gu, Heo, Jung, Kim, Sang-Hoon, Choi, Yuna, Song, Seungri, Son, Hye Young, Kim, Se Hoon, Lee, Ji Hyun, Haam, Seung Joo, Huh, Yong Min, Chang, Jong Hee, Joo, Chulmin, Suh, Jin-Suck
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 26.10.2016
Nature Publishing Group
Subjects
631/67/2321
639/624/1107/510
Animals
Blood-brain barrier
Brain cancer
Brain research
Brain tumors
Contrast agents
Glioma
Glioma - diagnostic imaging
Glioma - metabolism
Glioma - pathology
Hospitals
Humanities and Social Sciences
Humans
Magnetic resonance imaging
Male
Medical prognosis
Medical schools
Medicine
Methods
Mice
Mice, Inbred BALB C
Mice, Nude
multidisciplinary
Neoplasms, Experimental - diagnostic imaging
Neoplasms, Experimental - metabolism
Neoplasms, Experimental - pathology
Neuroimaging
Research centers
Science
Surgery
Survival
Terahertz Imaging - methods
Tumors
University colleges
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Summary:Gross total resection (GTR) of glioma is critical for improving the survival rate of glioma patients. One of the greatest challenges for achieving GTR is the difficulty in discriminating low grade tumor or peritumor regions that have an intact blood brain barrier (BBB) from normal brain tissues and delineating glioma margins during surgery. Here we present a highly sensitive, label-free terahertz reflectometry imaging (TRI) that overcomes current key limitations for intraoperative detection of World Health Organization (WHO) grade II (low grade), and grade III and IV (high grade) gliomas. We demonstrate that TRI provides tumor discrimination and delineation of tumor margins in brain tissues with high sensitivity on the basis of Hematoxylin and eosin (H&E) stained image. TRI may help neurosurgeons to remove gliomas completely by providing visualization of tumor margins in WHO grade II, III, and IV gliomas without contrast agents, and hence, improve patient outcomes.
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These authors contributed equally to this work.
These authors jointly supervised this work.
ISSN:2045-2322
2045-2322
DOI:10.1038/srep36040