Translational regulation in response to stress in Saccharomyces cerevisiae

The budding yeast Saccharomyces cerevisiae must dynamically alter the composition of its proteome in order to respond to diverse stresses. The reprogramming of gene expression during stress typically involves initial global repression of protein synthesis, accompanied by the activation of stress‐res...

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Bibliographic Details
Published inYeast (Chichester, England) Vol. 36; no. 1; pp. 5 - 21
Main Authors Crawford, Robert A., Pavitt, Graham D.
Format Journal Article
LanguageEnglish
Published England Wiley Subscription Services, Inc 01.01.2019
John Wiley and Sons Inc
Subjects
eIF2 phosphorylation
Environmental conditions
Gene expression
Gene Expression Regulation, Fungal
Protein Biosynthesis
Protein Processing, Post-Translational
Proteomes
Regulatory sequences
ribosome filter
Ribosomes
Ribosomes - genetics
RNA, Messenger - genetics
RNA-binding protein
RNA-Binding Proteins - genetics
RNA‐binding proteins
Saccharomyces cerevisiae
Saccharomyces cerevisiae - genetics
Saccharomyces cerevisiae Proteins - genetics
Special Issue
Specialization
specialized ribosomes
Stress, Physiological
Transcription
Translation
translational control
Yeast
eIF2 phosphorylation
specialized ribosomes
RNA-binding proteins
ribosome filter
translational control
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Summary:The budding yeast Saccharomyces cerevisiae must dynamically alter the composition of its proteome in order to respond to diverse stresses. The reprogramming of gene expression during stress typically involves initial global repression of protein synthesis, accompanied by the activation of stress‐responsive mRNAs through both translational and transcriptional responses. The ability of specific mRNAs to counter the global translational repression is therefore crucial to the overall response to stress. Here we summarize the major repressive mechanisms and discuss mechanisms of translational activation in response to different stresses in S. cerevisiae. Taken together, a wide range of studies indicate that multiple elements act in concert to bring about appropriate translational responses. These include regulatory elements within mRNAs, altered mRNA interactions with RNA‐binding proteins and the specialization of ribosomes that each contribute towards regulating protein expression to suit the changing environmental conditions.
ISSN:0749-503X
1097-0061
DOI:10.1002/yea.3349