Calciphylaxis: Controversies in Pathogenesis, Diagnosis and Treatment

Calcific uremic arteriolopathy, otherwise known as calciphylaxis, is a rare disease characterized by skin ulceration and tissue necrosis, likely the result of vascular calcification with accompanying intimal hypertrophy and small vessel thrombosis. Although most often associated with end-stage renal...

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Bibliographic Details
Published inThe American journal of the medical sciences Vol. 351; no. 2; p. 217
Main Authors Jeong, Haneol S, Dominguez, Arturo R
Format Journal Article
LanguageEnglish
Published United States 01.02.2016
Subjects
Animals
Calciphylaxis - diagnosis
Calciphylaxis - etiology
Calciphylaxis - physiopathology
Calciphylaxis - therapy
Humans
Kidney Failure, Chronic - complications
Rats
Risk Factors
Calcific uremic arteriolopathy
Calciphylaxis
Treatment
Diagnosis
Pathogenesis
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Summary:Calcific uremic arteriolopathy, otherwise known as calciphylaxis, is a rare disease characterized by skin ulceration and tissue necrosis, likely the result of vascular calcification with accompanying intimal hypertrophy and small vessel thrombosis. Although most often associated with end-stage renal disease, it has also been seen in a number of other disorders (collectively referred to as nonuremic calciphylaxis). The purpose of this review is to summarize and analyze the currently available literature regarding the pathophysiology, risk factors, clinical presentation, diagnostic features and treatment modalities for this exceptionally uncommon illness. A series of recommended treatments is proposed for optimal treatment of calciphylaxis lesions.
ISSN:1538-2990
DOI:10.1016/j.amjms.2015.11.015