Effects of antipsychotic drugs on metabolite ratios in rat brain in vivo

• Published in: Magnetic resonance in medicine Vol. 43; no. 3; pp. 355 - 358
• Main Authors: Lindquist, Diana M., Hawk, Roger M., Karson, Craig N., Komoroski, Richard A.
• Format: Journal Article
• Language: English
• Published: New York John Wiley & Sons, Inc 01.03.2000; Williams & Wilkins
• Subjects: Analysis of Variance; Animals; Antipsychotic Agents - pharmacology; Aspartic Acid - analogs & derivatives; Aspartic Acid - metabolism; Benzodiazepines; Biochemistry and metabolism; Biological and medical sciences; Brain - metabolism; Central nervous system; Choline - metabolism; clozapine; Clozapine - pharmacology; Creatine - metabolism; Fundamental and applied biological sciences. Psychology; haloperidol; Haloperidol - pharmacology; Investigative techniques, diagnostic techniques (general aspects); Magnetic Resonance Spectroscopy; Male; Medical sciences; Nervous system; neuroleptic; Olanzapine; Pirenzepine - analogs & derivatives; Pirenzepine - pharmacology; Radiodiagnosis. Nmr imagery. Nmr spectrometry; Rats; Rats, Sprague-Dawley; schizophrenia; Vertebrates: nervous system and sense organs; Creatinine; Animal model; Rat; Rodentia; Central nervous system; Aspartate; NMR spectrometry; Experimental study; Metabolism; In vivo; Vertebrata; Mammalia; Animal; Choline; Antipsychotic; Biological effect; Brain (vertebrata)
• ISSN: 0740-3194; 1522-2594
• DOI: 10.1002/(SICI)1522-2594(200003)43:3<355::AID-MRM6>3.0.CO;2-R

Localized in vivo proton magnetic resonance spectroscopy at 4.7 T was used to examine the brains of rats that were given the antipsychotic drugs haloperidol, clozapine, or olanzapine for 1 week. Spectra were collected before and during treatment. The ratios of N‐acetylaspartate (NAA) to creatine (Cr) and choline to Cr were determined from the spectra. No significant differences in these ratios were seen among the rats given the various antipsychotic medications or between the control rats and the treated rats. No significant time‐dependent changes were seen in most cases, except for a small reduction of NAA/Cr after 7 days of olanzapine administration. These results suggest that differences in brain metabolite ratios in vivo in schizophrenics relative to controls, at least for short‐term treatment, arise from the disease, and not as a metabolic effect of the medication. Magn Reson Med 43:355–358, 2000. © 2000 Wiley‐Liss, Inc.