Dynamics and Stabilization of the Human Gut Microbiome during the First Year of Life

• Published in: Cell host & microbe Vol. 17; no. 5; pp. 690 - 703
• Main Authors: Bäckhed, Fredrik, Roswall, Josefine, Peng, Yangqing, Feng, Qiang, Jia, Huijue, Kovatcheva-Datchary, Petia, Li, Yin, Xia, Yan, Xie, Hailiang, Zhong, Huanzi, Khan, Muhammad Tanweer, Zhang, Jianfeng, Li, Junhua, Xiao, Liang, Al-Aama, Jumana, Zhang, Dongya, Lee, Ying Shiuan, Kotowska, Dorota, Colding, Camilla, Tremaroli, Valentina, Yin, Ye, Bergman, Stefan, Xu, Xun, Madsen, Lise, Kristiansen, Karsten, Dahlgren, Jovanna, Wang, Jun
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 13.05.2015
• Subjects: Adult; BACTERIA; Breast Feeding; CHILDREN; Delivery, Obstetric - methods; DISEASE; Feces - microbiology; Gastrointestinal Microbiome; Gastrointestinal Tract - microbiology; Humans; Infant; INFANT GUT; Infant, Newborn; INTESTINAL MICROBIOTA; MELATONIN; METAGENOME; Metagenomics; Microbiology; Microbiota; Molecular Sequence Data; NEWBORNS; Parasitology; Pediatrics; Pediatrik; PROTEINS; Sequence Analysis, DNA; Sweden; Virology; Sweden
• ISSN: 1931-3128; 1934-6069; 1934-6069
• DOI: 10.1016/j.chom.2015.04.004

The gut microbiota is central to human health, but its establishment in early life has not been quantitatively and functionally examined. Applying metagenomic analysis on fecal samples from a large cohort of Swedish infants and their mothers, we characterized the gut microbiome during the first year of life and assessed the impact of mode of delivery and feeding on its establishment. In contrast to vaginally delivered infants, the gut microbiota of infants delivered by C-section showed significantly less resemblance to their mothers. Nutrition had a major impact on early microbiota composition and function, with cessation of breast-feeding, rather than introduction of solid food, being required for maturation into an adult-like microbiota. Microbiota composition and ecological network had distinctive features at each sampled stage, in accordance with functional maturation of the microbiome. Our findings establish a framework for understanding the interplay between the gut microbiome and the human body in early life. [Display omitted] •Gut microbiomes of 98 mothers and their infants during the first year of life was assessed•Cessation of breast-feeding drives the maturation of the infant gut microbiome•Shifts in signature species demonstrate nonrandom transitions in the infants’ gut•Changes in nutrient and xenobiotic metabolism mark maturation of the gut microbiome Bäckhed et al. assessed the gut microbiomes of 98 Swedish mothers and their infants during the first year of life. Cessation of breast-feeding was identified as a major factor in determining gut microbiota maturation, with distinct shifts in signature species being hallmarks of its functional maturation.