Combined respiratory training in an individual with C9orf72 amyotrophic lateral sclerosis

This case study examined the impact of a respiratory strength training program targeting inspiratory and expiratory musculature in an individual with C9orf72 amyotrophic lateral sclerosis (ALS). The individual tolerated 24 months of respiratory training completed at home, 50 repetitions per day, and...

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Bibliographic Details
Published inAnnals of clinical and translational neurology Vol. 5; no. 9; pp. 1134 - 1138
Main Authors Robison, Raele, Tabor‐Gray, Lauren C., Wymer, James P., Plowman, Emily K.
Format Journal Article
LanguageEnglish
Published United States John Wiley & Sons, Inc 01.09.2018
John Wiley and Sons Inc
Wiley
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Summary:This case study examined the impact of a respiratory strength training program targeting inspiratory and expiratory musculature in an individual with C9orf72 amyotrophic lateral sclerosis (ALS). The individual tolerated 24 months of respiratory training completed at home, 50 repetitions per day, and 5 days per week. Significant increases in maximum inspiratory pressure (from 71 to 134 centimeters of water), maximum expiratory pressure (from 108 to 197 centimeters of water) and peak cough flow (from 331 to 655 Liters per minute) were noted and forced vital capacity remained unchanged. A moderate intensity respiratory strength training program applied early in the disease progression improved function in this C9orf72 ALS individual.
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This study was funded by the ALS Association [clinical management grant 17‐CM‐323].
ISSN:2328-9503
2328-9503
DOI:10.1002/acn3.623