The Herpes Simplex Virus Type 2 R1 Protein Kinase (ICP10 PK) Blocks Apoptosis in Hippocampal Neurons, Involving Activation of the MEK/MAPK Survival Pathway

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Published inJournal of Virology Vol. 76; no. 3; pp. 1435 - 1449
Main Authors Perkins, D, Pereira, E F R, Gober, M, Yarowsky, P J, Aurelian, L
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 01.02.2002
Subjects
Animals
Apoptosis
Caspase 3
Caspases - metabolism
Cell Differentiation
Cell Line
Cells, Cultured
Cercopithecus aethiops
DNA Fragmentation
Enzyme Activation
Herpes simplex virus 2
Herpesvirus 2, Human - physiology
Hippocampus - cytology
Humans
In Situ Nick-End Labeling
Mannitol - pharmacology
MAP Kinase Signaling System
MAPK protein
MEK protein
Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors
Mitogen-Activated Protein Kinase Kinases - metabolism
Mitogen-Activated Protein Kinases - metabolism
Nerve Growth Factors
Neurons - cytology
Neurons - virology
PC12 Cells
Poly(ADP-ribose) Polymerases - metabolism
Protein-Serine-Threonine Kinases - genetics
Protein-Serine-Threonine Kinases - physiology
Ras protein
Rats
Rats, Sprague-Dawley
Ribonucleotide Reductases - genetics
Ribonucleotide Reductases - physiology
Staurosporine - pharmacology
Transfection
Vero Cells
Viral Proteins - biosynthesis
Virus-Cell Interactions
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Summary:Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue JVI About JVI Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy JVI RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0022-538X Online ISSN: 1098-5514 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to JVI .asm.org, visit: JVI       
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Corresponding author. Mailing address: Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, 10 S. Pine St., Baltimore, MD 21201. Phone: (410) 706-3895. Fax: (410) 706-2513. E-mail: laurelia@umaryland.edu.
ISSN:0022-538X
1098-5514
DOI:10.1128/JVI.76.3.1435-1449.2002