A combination of soy isoflavones and cello-oligosaccharides changes equol/O-desmethylangolensin production ratio and attenuates bone fragility in ovariectomized mice

• Published in: Bioscience, biotechnology, and biochemistry Vol. 80; no. 8; pp. 1632 - 1635
• Main Authors: Fujii, Shungo, Takahashi, Nobuyuki, Inoue, Hirofumi, Katsumata, Shin-ichi, Kikkawa, Yuji, Machida, Makoto, Ishimi, Yoshiko, Uehara, Mariko
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 01.08.2016
• Subjects: Absorptiometry, Photon; Animals; Bone Density - drug effects; cello-oligosaccharides; Cellobiose - administration & dosage; equol; Equol - urine; Female; Femur - drug effects; Femur - metabolism; Femur - pathology; Food, Formulated; Fractures, Bone - metabolism; Fractures, Bone - pathology; Fractures, Bone - prevention & control; Genistein - urine; Glycine max - chemistry; isoflavones; Isoflavones - administration & dosage; Isoflavones - urine; Mice; O-desmethylangolensin; osteoporosis; Ovariectomy; equol; O-desmethylangolensin; isoflavones; cello-oligosaccharides; osteoporosis
• ISSN: 0916-8451; 1347-6947
• DOI: 10.1080/09168451.2016.1184559

We examined the cooperative effects of isoflavones and cello-oligosaccharides on daidzein metabolism and bone fragility in ovariectomized mice. Cello-oligosaccharides increased urinary equol and decreased O-desmethylangolensin. A combination of isoflavones and cello-oligosaccharides attenuated decreases in bone breaking force and stiffness caused by ovariectomy. Combination treatment with isofalvones and cello-oligosaccharides increases urinary equol/O-desmethylangolensin production ratio and prevents ovariectomy-induced abnormalities in bone strength.