Eligibility of C-BIOPRED severe asthma cohort for type-2 biologic therapies
Patients not eligible for any biologic treatments were characterized by the highest FeNO (33.2 ppb, P < 0.001), with raised sputum eosinophils and BEC (270/μL) and none received OCS therapy. Because the UK National Health and Care Institute has advocated the use of these biologics using different...
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Published in | Chinese medical journal Vol. 136; no. 2; pp. 230 - 232 |
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Main Authors | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
China
Lippincott Williams & Wilkins Ovid Technologies
20.01.2023
Lippincott Williams & Wilkins Wolters Kluwer |
Subjects | |
Online Access | Get full text |
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Summary: | Patients not eligible for any biologic treatments were characterized by the highest FeNO (33.2 ppb, P < 0.001), with raised sputum eosinophils and BEC (270/μL) and none received OCS therapy. Because the UK National Health and Care Institute has advocated the use of these biologics using different criteria (https://www.nice.org.uk/guidance/TA751/chapter/1-Recommendations), we have examined these conditions such as the need for having more than four severe exacerbations in the previous year and the combination of BEC ≥150/μL plus FeNO ≥25 ppb for consideration of severe asthma patients for anti-IL4Rα. [...]extending the cut-off point of 1, 2, 3, or 4 exacerbations in the previous year, those eligible for the biologic therapies would be 58.8%, 38.5%, 23.0%, and 15.3%, respectively [Supplementary Table 1, http://links.lww.com/CM9/B402]. [...]many of the 42.0% of severe asthma patients not eligible for biologic therapies represent those who do not report two or more exacerbations in the previous year, particularly in those with atopy and high BECs. [...]this study reveals that T2-high asthma is the predominant phenotype in patients with severe asthma in the C-BIOPRED cohort and remains relatively stable after a 1-year longitudinal visit. |
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Bibliography: | SourceType-Other Sources-1 content type line 63 ObjectType-Correspondence-1 |
ISSN: | 2542-5641 0366-6999 2542-5641 |
DOI: | 10.1097/CM9.0000000000002556 |