New Carbocyclic Amino Acid Derivatives Inhibit Infection Caused by Highly Pathogenic Influenza A Virus Strain (H5N1)

• Published in: Bulletin of experimental biology and medicine Vol. 161; no. 2; pp. 284 - 287
• Main Authors: Shibnev, V. A., Garaev, T. M., Deryabin, P. G., Finogenova, M. P., Botikov, A. G., Mishin, D. V.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.06.2016; Springer; Springer Nature B.V
• Subjects: Amino acids; Amino Acids - pharmacology; Animals; Antiviral agents; Antiviral Agents - pharmacology; Avian influenza; Avian influenza viruses; Biomedical and Life Sciences; Biomedicine; Cell Biology; Cells, Cultured; Drug Evaluation, Preclinical; Health aspects; Influenza A virus; Influenza A Virus, H5N1 Subtype - drug effects; Influenza A Virus, H5N1 Subtype - physiology; Inhibitory Concentration 50; Internal Medicine; Laboratory Medicine; Orthomyxoviridae; Pathology; Rimantadine - pharmacology; Sus scrofa; Virus Replication - drug effects; influenza A/H5N1 virus; antiviral activity; remantadine; adamantane derivatives; amino acids
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-016-3396-0

New amino acid derivatives with carbocycles of adamantine and quinaldic acid were synthesized and their in vitro antiviral activity against influenza A/H5N1 virus was evaluated. Experiments on cultured embryonic porcine kidney epithelial cells showed that amino acid derivatives suppressed viral replication. Tret-butyloxycarbonyl-DL-methionylsulfonyl-1-adamantayl ethylamine and benzyloxycarbonyl-L-trypthophanyl-1-adamantayl ethylamine compounds demonstrated high activity in all in vitro experiments. Moreover, some compounds showed virucidal activity against influenza A/H5N1 virus.