Plant Polysaccharides Attenuate Fluorouracil Toxicity for the Small Intestinal Epithelium

Polysaccharides from Tussilago farfara L. , Acorus calamus L. , and Echinacea purpurea (L.) Moench attenuated the toxic effect of fl uorouracil on the small intestinal epithelium of mice with Lewis lung carcinoma. Addition of polysaccharides to chemotherapy protocols stimulated reparative regenerati...

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Published inBulletin of experimental biology and medicine Vol. 161; no. 2; pp. 308 - 311
Main Authors Safonova, E. A., Lopatina, K. A., Vychuzhanina, A. V., Ermolaeva, L. A., Razina, T. G., Zueva, E. P.
Format Journal Article
LanguageEnglish
Published New York Springer US 01.06.2016
Springer
Springer Nature B.V
Subjects
Acorus calamus
Animals
Antimetabolites, Antineoplastic - therapeutic use
Antimetabolites, Antineoplastic - toxicity
Antineoplastic agents
Biomedical and Life Sciences
Biomedicine
Carcinoma, Lewis Lung - drug therapy
Cell Biology
Chemotherapy
Complications and side effects
Drug Screening Assays, Antitumor
Echinacea purpurea
Epithelium
Female
Fluorouracil - therapeutic use
Fluorouracil - toxicity
Gastrointestinal system
Internal Medicine
Intestinal Mucosa - drug effects
Intestinal Mucosa - pathology
Intestine, Small - drug effects
Intestine, Small - pathology
Laboratory Medicine
Lung cancer
Mice, Inbred C57BL
Neoplasm Transplantation
Pathology
Plant Extracts - pharmacology
Polysaccharides
Toxicity
Tussilago farfara
polysaccharides
toxicity
small intestinal epithelium
fluorouracil
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Abstract Polysaccharides from Tussilago farfara L. , Acorus calamus L. , and Echinacea purpurea (L.) Moench attenuated the toxic effect of fl uorouracil on the small intestinal epithelium of mice with Lewis lung carcinoma. Addition of polysaccharides to chemotherapy protocols stimulated reparative regeneration processes in the small intestine damaged by the cytostatic treatment. No stimulating effects of the polysaccharides on tumor growth and metastasizing were revealed.
AbstractList Polysaccharides from Tussilago farfara L. , Acorus calamus L. , and Echinacea purpurea (L.) Moench attenuated the toxic effect of fl uorouracil on the small intestinal epithelium of mice with Lewis lung carcinoma. Addition of polysaccharides to chemotherapy protocols stimulated reparative regeneration processes in the small intestine damaged by the cytostatic treatment. No stimulating effects of the polysaccharides on tumor growth and metastasizing were revealed.
Polysaccharides from Tussilago farfara L., Acorus calamus L., and Echinacea purpurea (L.) Moench attenuated the toxic effect of fluorouracil on the small intestinal epithelium of mice with Lewis lung carcinoma. Addition of polysaccharides to chemotherapy protocols stimulated reparative regeneration processes in the small intestine damaged by the cytostatic treatment. No stimulating effects of the polysaccharides on tumor growth and metastasizing were revealed. Key Words: polysaccharides; fluorouracil; toxicity; small intestinal epithelium
Polysaccharides from Tussilago farfara L., Acorus calamus L., and Echinacea purpurea (L.) Moench attenuated the toxic effect of fl uorouracil on the small intestinal epithelium of mice with Lewis lung carcinoma. Addition of polysaccharides to chemotherapy protocols stimulated reparative regeneration processes in the small intestine damaged by the cytostatic treatment. No stimulating effects of the polysaccharides on tumor growth and metastasizing were revealed.
Polysaccharides from Tussilago farfara L., Acorus calamus L., and Echinacea purpurea (L.) Moench attenuated the toxic effect of fluorouracil on the small intestinal epithelium of mice with Lewis lung carcinoma. Addition of polysaccharides to chemotherapy protocols stimulated reparative regeneration processes in the small intestine damaged by the cytostatic treatment. No stimulating effects of the polysaccharides on tumor growth and metastasizing were revealed.
Audience Academic
Author Razina, T. G.
Zueva, E. P.
Lopatina, K. A.
Safonova, E. A.
Ermolaeva, L. A.
Vychuzhanina, A. V.
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crossref_primary_10_1007_s00761_019_0625_y
crossref_primary_10_1016_j_jep_2020_113478
Cites_doi 10.1007/s10517-006-0229-6
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Keywords polysaccharides
toxicity
small intestinal epithelium
fluorouracil
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Snippet Polysaccharides from Tussilago farfara L. , Acorus calamus L. , and Echinacea purpurea (L.) Moench attenuated the toxic effect of fl uorouracil on the small...
Polysaccharides from Tussilago farfara L., Acorus calamus L., and Echinacea purpurea (L.) Moench attenuated the toxic effect of fl uorouracil on the small...
Polysaccharides from Tussilago farfara L., Acorus calamus L., and Echinacea purpurea (L.) Moench attenuated the toxic effect of fluorouracil on the small...
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StartPage 308
SubjectTerms Acorus calamus
Animals
Antimetabolites, Antineoplastic - therapeutic use
Antimetabolites, Antineoplastic - toxicity
Antineoplastic agents
Biomedical and Life Sciences
Biomedicine
Carcinoma, Lewis Lung - drug therapy
Cell Biology
Chemotherapy
Complications and side effects
Drug Screening Assays, Antitumor
Echinacea purpurea
Epithelium
Female
Fluorouracil - therapeutic use
Fluorouracil - toxicity
Gastrointestinal system
Internal Medicine
Intestinal Mucosa - drug effects
Intestinal Mucosa - pathology
Intestine, Small - drug effects
Intestine, Small - pathology
Laboratory Medicine
Lung cancer
Mice, Inbred C57BL
Neoplasm Transplantation
Pathology
Plant Extracts - pharmacology
Polysaccharides
Toxicity
Tussilago farfara
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Title Plant Polysaccharides Attenuate Fluorouracil Toxicity for the Small Intestinal Epithelium
URI https://link.springer.com/article/10.1007/s10517-016-3402-6
https://www.ncbi.nlm.nih.gov/pubmed/27383155
https://www.proquest.com/docview/1860893350
https://search.proquest.com/docview/1811898331
Volume 161
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