Plant Polysaccharides Attenuate Fluorouracil Toxicity for the Small Intestinal Epithelium

• Published in: Bulletin of experimental biology and medicine Vol. 161; no. 2; pp. 308 - 311
• Main Authors: Safonova, E. A., Lopatina, K. A., Vychuzhanina, A. V., Ermolaeva, L. A., Razina, T. G., Zueva, E. P.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.06.2016; Springer; Springer Nature B.V
• Subjects: Acorus calamus; Animals; Antimetabolites, Antineoplastic - therapeutic use; Antimetabolites, Antineoplastic - toxicity; Antineoplastic agents; Biomedical and Life Sciences; Biomedicine; Carcinoma, Lewis Lung - drug therapy; Cell Biology; Chemotherapy; Complications and side effects; Drug Screening Assays, Antitumor; Echinacea purpurea; Epithelium; Female; Fluorouracil - therapeutic use; Fluorouracil - toxicity; Gastrointestinal system; Internal Medicine; Intestinal Mucosa - drug effects; Intestinal Mucosa - pathology; Intestine, Small - drug effects; Intestine, Small - pathology; Laboratory Medicine; Lung cancer; Mice, Inbred C57BL; Neoplasm Transplantation; Pathology; Plant Extracts - pharmacology; Polysaccharides; Toxicity; Tussilago farfara; polysaccharides; toxicity; small intestinal epithelium; fluorouracil
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-016-3402-6

Polysaccharides from Tussilago farfara L. , Acorus calamus L. , and Echinacea purpurea (L.) Moench attenuated the toxic effect of fl uorouracil on the small intestinal epithelium of mice with Lewis lung carcinoma. Addition of polysaccharides to chemotherapy protocols stimulated reparative regeneration processes in the small intestine damaged by the cytostatic treatment. No stimulating effects of the polysaccharides on tumor growth and metastasizing were revealed.