Effect of single-dose methotrexate on ovarian reserve in women with ectopic pregnancy

Objective To evaluate ovarian reserve in women with ectopic pregnancy treated with single-dose systemic methotrexate in the early post-treatment period. Design Prospective study. Setting Women’s health education and research hospital. Patient (s) Eighty-two patients with ectopic pregnancy and 80 hea...

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Published inFertility and sterility Vol. 100; no. 5; pp. 1310 - 1313
Main Authors Uyar, Ibrahim, M.D, Yucel, Onur Umut, M.D, Gezer, Cenk, M.D, Gulhan, Ibrahim, M.D, Karis, Buket, M.D, Hanhan, H. Merih, M.D, Ozeren, Mehmet, M.D
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.11.2013
Subjects
Abortifacient Agents, Nonsteroidal - administration & dosage
Abortifacient Agents, Nonsteroidal - adverse effects
Adult
animal ovaries
Biomarkers - blood
Case-Control Studies
ectopic pregnancy
educational research
Estradiol - blood
Female
Follicle Stimulating Hormone, Human - blood
follicle-stimulating hormone
health education
Humans
Internal Medicine
laparoscopy
laparotomy
menstrual cycle
methotrexate
Methotrexate - administration & dosage
Methotrexate - adverse effects
methotrexate treatment
Obstetrics and Gynecology
Ovarian reserve
Ovary - diagnostic imaging
Ovary - drug effects
Ovary - metabolism
Ovary - physiopathology
patients
Pregnancy
Pregnancy, Ectopic - diagnosis
Prospective Studies
Treatment Outcome
Ultrasonography
women
Young Adult
methotrexate treatment
Ovarian reserve
ectopic pregnancy
Online AccessGet full text

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Abstract Objective To evaluate ovarian reserve in women with ectopic pregnancy treated with single-dose systemic methotrexate in the early post-treatment period. Design Prospective study. Setting Women’s health education and research hospital. Patient (s) Eighty-two patients with ectopic pregnancy and 80 healthy women in the same age group were included in the study. Of the 82 patients, 49 with ectopic pregnancy were treated with single-dose systemic methotrexate (MTX) and 33 were treated surgically with laparoscopy or laparotomy (salpingectomy or salpingostomy). Intervention(s) Ovarian reserve testing. Main Outcome Measure(s) Basal FSH on the 3rd day of the menstrual cycle, E2 , basal antral follicle count (AFC), and ovarian volume. Result(s) There were no differences among the groups in terms of basal FSH, E2 , AFC, and ovarian volume. Conclusion(s) The single-dose MTX treatment had no effect on ovarian reserve in women with ectopic pregnancy as measured by the above-mentioned parameters.
AbstractList To evaluate ovarian reserve in women with ectopic pregnancy treated with single-dose systemic methotrexate in the early post-treatment period. Prospective study. Women's health education and research hospital. Eighty-two patients with ectopic pregnancy and 80 healthy women in the same age group were included in the study. Of the 82 patients, 49 with ectopic pregnancy were treated with single-dose systemic methotrexate (MTX) and 33 were treated surgically with laparoscopy or laparotomy (salpingectomy or salpingostomy). Ovarian reserve testing. Basal FSH on the 3rd day of the menstrual cycle, E₂, basal antral follicle count (AFC), and ovarian volume. There were no differences among the groups in terms of basal FSH, E₂, AFC, and ovarian volume. The single-dose MTX treatment had no effect on ovarian reserve in women with ectopic pregnancy as measured by the above-mentioned parameters.
OBJECTIVE: To evaluate ovarian reserve in women with ectopic pregnancy treated with single-dose systemic methotrexate in the early post-treatment period. DESIGN: Prospective study. SETTING: Women’s health education and research hospital. PATIENT (S): Eighty-two patients with ectopic pregnancy and 80 healthy women in the same age group were included in the study. Of the 82 patients, 49 with ectopic pregnancy were treated with single-dose systemic methotrexate (MTX) and 33 were treated surgically with laparoscopy or laparotomy (salpingectomy or salpingostomy). INTERVENTION(S): Ovarian reserve testing. MAIN OUTCOME MEASURE(S): Basal FSH on the 3rd day of the menstrual cycle, E₂, basal antral follicle count (AFC), and ovarian volume. RESULT(S): There were no differences among the groups in terms of basal FSH, E₂, AFC, and ovarian volume. CONCLUSION(S): The single-dose MTX treatment had no effect on ovarian reserve in women with ectopic pregnancy as measured by the above-mentioned parameters.
Objective To evaluate ovarian reserve in women with ectopic pregnancy treated with single-dose systemic methotrexate in the early post-treatment period. Design Prospective study. Setting Women’s health education and research hospital. Patient (s) Eighty-two patients with ectopic pregnancy and 80 healthy women in the same age group were included in the study. Of the 82 patients, 49 with ectopic pregnancy were treated with single-dose systemic methotrexate (MTX) and 33 were treated surgically with laparoscopy or laparotomy (salpingectomy or salpingostomy). Intervention(s) Ovarian reserve testing. Main Outcome Measure(s) Basal FSH on the 3rd day of the menstrual cycle, E2 , basal antral follicle count (AFC), and ovarian volume. Result(s) There were no differences among the groups in terms of basal FSH, E2 , AFC, and ovarian volume. Conclusion(s) The single-dose MTX treatment had no effect on ovarian reserve in women with ectopic pregnancy as measured by the above-mentioned parameters.
To evaluate ovarian reserve in women with ectopic pregnancy treated with single-dose systemic methotrexate in the early post-treatment period. Prospective study. Women’s health education and research hospital. Eighty-two patients with ectopic pregnancy and 80 healthy women in the same age group were included in the study. Of the 82 patients, 49 with ectopic pregnancy were treated with single-dose systemic methotrexate (MTX) and 33 were treated surgically with laparoscopy or laparotomy (salpingectomy or salpingostomy). Ovarian reserve testing. Basal FSH on the 3rd day of the menstrual cycle, E2, basal antral follicle count (AFC), and ovarian volume. There were no differences among the groups in terms of basal FSH, E2, AFC, and ovarian volume. The single-dose MTX treatment had no effect on ovarian reserve in women with ectopic pregnancy as measured by the above-mentioned parameters.
Author Ozeren, Mehmet
Gezer, Cenk
Yucel, Onur Umut
Gulhan, Ibrahim
Uyar, Ibrahim
Karis, Buket
Hanhan, H. Merih
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Issue 5
Keywords methotrexate treatment
Ovarian reserve
ectopic pregnancy
Language English
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Snippet Objective To evaluate ovarian reserve in women with ectopic pregnancy treated with single-dose systemic methotrexate in the early post-treatment period. Design...
To evaluate ovarian reserve in women with ectopic pregnancy treated with single-dose systemic methotrexate in the early post-treatment period. Prospective...
OBJECTIVE: To evaluate ovarian reserve in women with ectopic pregnancy treated with single-dose systemic methotrexate in the early post-treatment period....
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SubjectTerms Abortifacient Agents, Nonsteroidal - administration & dosage
Abortifacient Agents, Nonsteroidal - adverse effects
Adult
animal ovaries
Biomarkers - blood
Case-Control Studies
ectopic pregnancy
educational research
Estradiol - blood
Female
Follicle Stimulating Hormone, Human - blood
follicle-stimulating hormone
health education
Humans
Internal Medicine
laparoscopy
laparotomy
menstrual cycle
methotrexate
Methotrexate - administration & dosage
Methotrexate - adverse effects
methotrexate treatment
Obstetrics and Gynecology
Ovarian reserve
Ovary - diagnostic imaging
Ovary - drug effects
Ovary - metabolism
Ovary - physiopathology
patients
Pregnancy
Pregnancy, Ectopic - diagnosis
Prospective Studies
Treatment Outcome
Ultrasonography
women
Young Adult
Title Effect of single-dose methotrexate on ovarian reserve in women with ectopic pregnancy
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https://dx.doi.org/10.1016/j.fertnstert.2013.06.040
https://www.ncbi.nlm.nih.gov/pubmed/23891021
Volume 100
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