Effect of single-dose methotrexate on ovarian reserve in women with ectopic pregnancy

• Published in: Fertility and sterility Vol. 100; no. 5; pp. 1310 - 1313
• Main Authors: Uyar, Ibrahim, M.D, Yucel, Onur Umut, M.D, Gezer, Cenk, M.D, Gulhan, Ibrahim, M.D, Karis, Buket, M.D, Hanhan, H. Merih, M.D, Ozeren, Mehmet, M.D
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2013
• Subjects: Abortifacient Agents, Nonsteroidal - administration & dosage; Abortifacient Agents, Nonsteroidal - adverse effects; Adult; animal ovaries; Biomarkers - blood; Case-Control Studies; ectopic pregnancy; educational research; Estradiol - blood; Female; Follicle Stimulating Hormone, Human - blood; follicle-stimulating hormone; health education; Humans; Internal Medicine; laparoscopy; laparotomy; menstrual cycle; methotrexate; Methotrexate - administration & dosage; Methotrexate - adverse effects; methotrexate treatment; Obstetrics and Gynecology; Ovarian reserve; Ovary - diagnostic imaging; Ovary - drug effects; Ovary - metabolism; Ovary - physiopathology; patients; Pregnancy; Pregnancy, Ectopic - diagnosis; Prospective Studies; Treatment Outcome; Ultrasonography; women; Young Adult; methotrexate treatment; Ovarian reserve; ectopic pregnancy
• ISSN: 0015-0282; 1556-5653
• DOI: 10.1016/j.fertnstert.2013.06.040

Objective To evaluate ovarian reserve in women with ectopic pregnancy treated with single-dose systemic methotrexate in the early post-treatment period. Design Prospective study. Setting Women’s health education and research hospital. Patient (s) Eighty-two patients with ectopic pregnancy and 80 healthy women in the same age group were included in the study. Of the 82 patients, 49 with ectopic pregnancy were treated with single-dose systemic methotrexate (MTX) and 33 were treated surgically with laparoscopy or laparotomy (salpingectomy or salpingostomy). Intervention(s) Ovarian reserve testing. Main Outcome Measure(s) Basal FSH on the 3rd day of the menstrual cycle, E2 , basal antral follicle count (AFC), and ovarian volume. Result(s) There were no differences among the groups in terms of basal FSH, E2 , AFC, and ovarian volume. Conclusion(s) The single-dose MTX treatment had no effect on ovarian reserve in women with ectopic pregnancy as measured by the above-mentioned parameters.