siRNA-mediated knockdown of the melanocortin 2 receptor accessory protein 2 (MRAP2) gene confers resistance to methylmercury on HEK293 cells

• Published in: Journal of toxicological sciences Vol. 35; no. 6; pp. 947 - 950
• Main Authors: Hwang, Gi-Wook, Oh, Seong-Eun, Takahashi, Tsutomu, Lee, Jin-Yong, Naganuma, Akira
• Format: Journal Article
• Language: English
• Published: Japan The Japanese Society of Toxicology 01.12.2010
• Subjects: Carrier Proteins - antagonists & inhibitors; Carrier Proteins - genetics; Drug Resistance - genetics; Environmental Pollutants - toxicity; HEK293 Cells; Humans; Ligands; Melanocortin; Methylmercury; Methylmercury Compounds - toxicity; MRAP2; Resistance; RNA, Small Interfering - genetics; Signal Transduction - drug effects

Methylmercury is a well-known environmental pollutant that causes serious disorders of the central nervous system as well as a range of other symptoms. We employed small interfering RNA (siRNA) to search for factors in ligand-dependent signal transduction pathways that may be involved in the develop...