Effect of Repeated 1-h Episodes of Immobilization Stress on Activity of Glucocorticoid Metabolism Enzymes in the Liver

• Published in: Bulletin of experimental biology and medicine Vol. 160; no. 5; pp. 614 - 616
• Main Authors: Tseilikman, V. E., Kozochkin, D. A., Sinitskii, A. I., Tseylikman, O. B., Lapshin, M. S., Kuzina, O. V., Komel’kova, M. V., Telesheva, I. B.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.03.2016; Springer; Springer Nature B.V
• Subjects: Analysis; Animals; Biomedical and Life Sciences; Biomedicine; Cell Biology; Corticosterone; Corticosterone - metabolism; Cytochrome P-450 CYP3A - metabolism; Enzymes; Glucocorticoids - metabolism; Immobilization; Interleukin-1beta - blood; Interleukin-6 - blood; Internal Medicine; Laboratory Medicine; Lipid Metabolism; Liver - enzymology; Liver - metabolism; Male; Oxidation-Reduction; Pathology; Physiological aspects; Rats; Rats, Wistar; Steroids (Organic compounds); Stress, Psychological - metabolism; corticosterone; stress; 11β-hydroxysteroid dehydrogenase-2, CYP3A
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-016-3230-8

Differences in corticosterone level associated with different activity of glucocorticoid-oxidizing enzymes in the liver were revealed in rats exposed to stress. Pro-inflammatory changes in the liver were associated with enhanced CYP3A-dependent monooxygenation.