Cell transplantation strategies for retinal repair

Cell transplantation is a novel therapeutic strategy to restore visual responses to the degenerate adult neural retina and represents an exciting area of regenerative neurotherapy. So far, it has been shown that transplanted postmitotic photoreceptor precursors are able to functionally integrate int...

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Published inProgress in Brain Research Vol. 175; pp. 3 - 21
Main Authors West, E.L., Pearson, R.A., MacLaren, R.E., Sowden, J.C., Ali, R.R.
Format Book Chapter Journal Article
LanguageEnglish
Published Netherlands Elsevier Science & Technology 2009
Subjects
Animals
degeneration
Humans
Mice
photoreceptor
Photoreceptor Cells - transplantation
progenitor cell
retina
Retina - transplantation
Retinal Diseases - surgery
stem cell
Stem Cell Transplantation - methods
transplantation
stem cell
retina
progenitor cell
degeneration
photoreceptor
transplantation
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Summary:Cell transplantation is a novel therapeutic strategy to restore visual responses to the degenerate adult neural retina and represents an exciting area of regenerative neurotherapy. So far, it has been shown that transplanted postmitotic photoreceptor precursors are able to functionally integrate into the adult mouse neural retina. In this review, we discuss the differentiation of photoreceptor cells from both adult and embryonic-derived stem cells and their potential for retinal cell transplantation. We also discuss the strategies used to overcome barriers present in the degenerate neural retina and improve retinal cell integration. Finally, we consider the future translation of retinal cell therapy as a therapeutic strategy to treat retinal degeneration.
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ISBN:012374511X
9780123745118
ISSN:0079-6123
1875-7855
DOI:10.1016/S0079-6123(09)17501-5