Effects of Antibodies to Glutamate on Focal Penicillin-Induced Epileptic Activity

• Published in: Bulletin of experimental biology and medicine Vol. 155; no. 5; pp. 609 - 611
• Main Authors: Kuznetsova, L. V., Karpova, M. N., Vetrile, L. A., Klishina, N. Yu
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.09.2013; Springer; Springer Nature B.V
• Subjects: Administration, Intranasal; Animals; Antibodies; Antibodies - pharmacology; Anticonvulsants - pharmacology; Biomedical and Life Sciences; Biomedicine; Cell Biology; Cerebral Cortex - drug effects; Cerebral Cortex - physiopathology; Electroencephalography; Epilepsies, Partial - chemically induced; Epilepsies, Partial - drug therapy; Epilepsies, Partial - immunology; Epilepsies, Partial - physiopathology; Glutamate; Glutamic Acid - immunology; Glutamic Acid - metabolism; Internal Medicine; Laboratory Medicine; Male; Motor Activity - drug effects; Pathology; Penicillin; Penicillins; Rats; Rats, Wistar; Seizures (Medicine); Viral antibodies; penicillin; antibodies; focal epileptic activity; glutamate
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-013-2206-1

The effects of intranasal pretreatment with antibodies against glutamate on focal penicillininduced epileptic activity were studied by recording electrocorticogram in non-anesthetized freely moving male Wistar rats. Anticonvulsant effects of intranasal administration of antiglutamate antibodies (300 μg/kg) 1 h before application of penicillin (30,000 U/ml) on the sensorimotor cortex was demonstrated: the latency of ictal discharges increased and their frequency decreased.