Pathomorphological and Immunohistochemical Analysis of Proliferative Activity of the Buccal Mucosal Epithelium in Lichen Planus

Structural reorganization of the buccal mucosa and changes in proliferative activity of epitheliocytes in typical and erosive ulcerative lichen planus were studied. The most manifest diagnostically significant pathomorphological signs of lichen planus of the buccal mucosa are described: acanthosis,...

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Published inBulletin of experimental biology and medicine Vol. 154; no. 2; pp. 283 - 286
Main Authors Timoshin, S. S., Fleishman, M. Yu, Zagorodnyaya, E. B., Oskol’skii, G. I., Zagorodnii, A. S., Lushnikova, E. L., Nepomnyashchikh, L. M.
Format Journal Article
LanguageEnglish
Published Boston Springer US 01.12.2012
Springer
Springer Nature B.V
Subjects
Biomedical and Life Sciences
Biomedicine
Cell Biology
Epithelium - metabolism
Epithelium - pathology
Female
Humans
Immunohistochemistry
Immunohistochemistry - methods
In Vitro Techniques
Internal Medicine
Ki-67 Antigen - metabolism
Laboratory Medicine
Lichen planus
Lichen Planus - metabolism
Lichen Planus - pathology
Male
Middle Aged
Morphology and Pathomorphology
Mouth Mucosa - metabolism
Mouth Mucosa - pathology
Pathology
buccal mucosa
immunohistochemistry
pathomorphology
lichen planus
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Summary:Structural reorganization of the buccal mucosa and changes in proliferative activity of epitheliocytes in typical and erosive ulcerative lichen planus were studied. The most manifest diagnostically significant pathomorphological signs of lichen planus of the buccal mucosa are described: acanthosis, granulosis, parakeratosis, lymphocytic infiltration of the lamina propria, and edema. The most pronounced morphological changes and higher index of epitheliocyte proliferative activity (by expression of Ki-67) are characteristic of the erosive ulcerative form of the disease.
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ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-012-1931-1