A double-blind randomized clinical trial of two carbamide peroxide tooth bleaching agents: 2-year follow-up

• Published in: Journal of dentistry Vol. 38; no. 12; pp. 956 - 963
• Main Authors: Meireles, S.S, Santos, I.S, Bona, A. Della, Demarco, F.F
• Format: Journal Article
• Language: English; Persian
• Published: Kidlington Elsevier Ltd 01.12.2010; Elsevier; Elsevier Limited
• Subjects: Beverages; Biological and medical sciences; Carbamide peroxide; Chi-Square Distribution; Clinical trials; Color; Confidence intervals; Cuspid; Dentistry; Diet; Dose-Response Relationship, Drug; Double-Blind Method; Ent. Stomatology; Follow-Up Studies; Head and neck surgery. Maxillofacial surgery. Dental surgery. Orthodontics; Humans; Incisor; Maxillofacial surgery. Dental surgery. Orthodontics; Medical sciences; Patient Satisfaction; Peroxides - administration & dosage; Pharmacology. Drug treatments; Randomized; Recurrence; Spectrophotometry; Standard deviation; Statistics, Nonparametric; Studies; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Tooth bleaching; Tooth Bleaching Agents - administration & dosage; Tooth Discoloration - therapy; Urea - administration & dosage; Urea - analogs & derivatives; Tooth bleaching; Clinical trials; Randomized; Carbamide peroxide; Human; Teeth; Dentistry; Urea; Bleaching; Follow up study; Double blind study; Clinical trial; Perception; Peroxides; Tooth; Bleaching agent; Food
• ISSN: 0300-5712; 1879-176X
• DOI: 10.1016/j.jdent.2010.08.003

Summary Objectives This double-blind randomized clinical trial aimed to evaluate the whitening effect of two at-home tooth bleaching agents and the effect of dietary habits after 2 years. The patients’ view about bleaching longevity was also investigated. Methods Ninety-two subjects with mean shade of C1 or darker for the six maxillary anterior teeth were randomized into two groups ( n = 46) according to the carbamide peroxide (CP) concentration: 10% (CP10) or 16% (CP16). The treatment was performed using the whitening agent in a tray for 2 h/day during 3 weeks. Shade evaluations were done with a shade guide and a spectrophotometer at baseline, 1-month, 6-month, 1-year and 2-year post-bleaching. Results Eighty-one (88%) of the original 92 subjects enrolled in the study were recalled at 2-year follow-up and, the tooth shade remained significantly lighter than at baseline, in both treatment groups, considering the tooth shade median values ( p < 0.001) or the color parameters: L * a * ( p < 0.001) for CP10 and, L * b * for CP16 group ( p < 0.001). Subjects from CP10 and CP16 reported a consumption of beverage and food stains as high as at 6-month and 1-year recalls and, more than 66% of the participants from each group reported a tooth shade relapse from mild to moderate ( p = 0.6). Significance At 2-year post-bleaching, tooth shade remained lighter than at baseline for both CP concentrations tested. Tooth shade relapse associated to increasing of a * and b * color parameters were observed for both groups when compared to the end of the treatment (CEP # 37/05).