Effects of Vascular Peptide Bioregulator on the Density of Microvascular Network in the Brain Cortex of Aged Rats

• Published in: Bulletin of experimental biology and medicine Vol. 161; no. 2; pp. 300 - 303
• Main Authors: Sokolova, I. B., Ryzhak, G. A., Mel’nikova, N. N., Sergeev, I. V., Khavinson, V. Kh
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.06.2016; Springer; Springer Nature B.V
• Subjects: Aging; Angiogenesis Inducing Agents - pharmacology; Animals; Biomedical and Life Sciences; Biomedicine; Cell Biology; Drug Evaluation, Preclinical; Internal Medicine; Laboratory Medicine; Male; Microvessels - drug effects; Neovascularization, Physiologic - drug effects; Pathology; Peptides; Pia Mater - blood supply; Proteins - pharmacology; Rats, Inbred WKY; Sensorimotor Cortex - blood supply; brain; angiogenesis; microvascular network density; vascular peptide bioregulator; arteriogenesis
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-016-3400-8

Using a TV unit for microcirculation studies, we studied the density of the entire microvascular network and its arterial compartment in the pia mater of the sensorimotor cortex in intact young and aged rats (2-3 and 22-24 months) and aged rats after a course of vascular peptide bioregulator Slavinorm. The experiments showed that the density of microvascular network in intact animals decreased by 1.6 times with aging. Treatment with the peptide bioregulator 2.5-fold increased the density of the microvascular network in aged rats in comparison with intact animals of the same age, the density of the arterial compartment of the microvascular network in the pia mater increased by 2.8 times.