Effects of Immunomodulators on Functional Activity of Innate Immunity Cells Infected with Streptococcus pneumoniae

• Published in: Bulletin of experimental biology and medicine Vol. 158; no. 4; pp. 461 - 464
• Main Authors: Plekhova, N. G., Kondrashova, N. M., Somova, L. M., Drobot, E. I., Lyapun, I. N.
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.02.2015; Springer; Springer Nature B.V
• Subjects: Animals; Bacterial pneumonia; Biomedical and Life Sciences; Biomedicine; Bisbenzimidazole; Cell Biology; Enzymes; Fluoroquinolones - pharmacology; Immunity, Innate - drug effects; Immunologic Factors - pharmacology; Immunomodulation - drug effects; Internal Medicine; Laboratory Medicine; Male; Mice; Microbiology and Immunology; Pathology; Phagocytes - drug effects; Pneumococcal Infections - drug therapy; Pneumonia; Streptococcus pneumoniae; immunomodulators; innate immunity cells; Streptococcus pneumonia; antibiotics; Apoptosis
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-015-2785-0

Low activity of bactericidal enzymes was found in innate immunity cells infected with S. pneumonia . The death of these cells was fastened under these conditions. On the contrary, treatment with antibiotic maxifloxacin was followed by an increase in activity of bactericidal enzymes in phagocytes and induced their death via necrosis. Analysis of the therapeutic properties of immunomodulators tinrostim and licopid in combination with maxifloxacin showed that these combinations correct functional activity of cells infected with S. pneumonia .