Associations of alcohol consumption and physical activity with lean type 2 diabetes mellitus among Korean adults: A prospective cohort study

• Published in: PloS one Vol. 15; no. 9; p. e0238641
• Main Authors: Baik, Inkyung, Park, Sang Ick
• Format: Journal Article
• Language: English
• Published: San Francisco Public Library of Science 03.09.2020; Public Library of Science (PLoS)
• Subjects: Alcohol; Alcohol use; Alcoholic beverages; Alcohols; Biology and Life Sciences; Body mass; Body mass index; Body size; Cohort analysis; Confidence intervals; Demographics; Diabetes; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Drug dosages; Epidemiology; Exercise; Glucose; Health risks; Human subjects; Medicine and Health Sciences; Mortality; Obesity; Physical activity; Questionnaires; Regression analysis; Researchers; Risk analysis; Risk factors; Risk management; Statistical analysis; Womens health; United States > US; South Korea
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0238641

Data on the association between alcohol consumption and the risk of type 2 diabetes mellitus (T2DM) have accumulated, but little has been reported about this association in terms of lean T2DM. The present study analyzed 10-year longitudinal data to investigate the association between alcohol consumption and T2DM risk among lean individuals. This prospective study included 2,366 male and female Koreans aged 40–69 years who were free of DM and had a body mass index (BMI) <23 kg/m2 during the baseline period between 2001 and 2012. Information on alcohol consumption, BMI, and incident cases of T2DM were identified by interviews and health examinations. To analyze the association between alcohol consumption and T2DM risk, Cox proportional hazard regression analysis was used. Alcohol drinkers consuming at least 16 g/day of alcohol (2 units/day) who maintained a BMI <23 kg/m2 over 10 years had a significantly higher T2DM risk even after controlling for BMI and potential risk factors. Compared with lifetime abstainers, multivariate hazard ratios (HR) [95% confidence interval] of T2DM were 1.74 [1.02, 2.95] for 16–30 g/day, 2.09 [1.16, 3.77] for 31–60 g/day, and 1.94 [1.07, 3.51] for >60g/day among alcohol drinkers. No protective effect of moderate alcohol consumption <16 g/day on T2DM risk was observed. Age, parental history of DM, and physical inactivity were also significant risk factors for lean T2DM. Alcohol consumption of at least 2 units/day increased T2DM risk among lean individuals. Abstaining from alcohol and physical activity may be beneficial for the prevention of lean T2DM.