Lumican, a Multifunctional Cell Instructive Biomarker Proteoglycan Has Novel Roles as a Marker of the Hypercoagulative State of Long Covid Disease

• Published in: International journal of molecular sciences Vol. 25; no. 5; p. 2825
• Main Authors: Smith, Margaret M, Melrose, James
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 29.02.2024; MDPI
• Subjects: anti-tumour; biomarker; Biomarkers; Blood proteins; Cell differentiation; Cell growth; Chondroitin Sulfate Proteoglycans - metabolism; Collagen; COVID-19; Development and progression; Health aspects; Humans; Inflammation; Kinases; Long COVID; Lumican; MMP inhibitor; Pathology; Post-Acute COVID-19 Syndrome; Proteoglycans; Review; tissue pathology; Type 2 diabetes; Yang Mu; MMP inhibitor; anti-tumour; lumican; biomarker; tissue pathology

This study has reviewed the many roles of lumican as a biomarker of tissue pathology in health and disease. Lumican is a structure regulatory proteoglycan of collagen-rich tissues, with cell instructive properties through interactions with a number of cell surface receptors in tissue repair, thereby...