Lumican, a Multifunctional Cell Instructive Biomarker Proteoglycan Has Novel Roles as a Marker of the Hypercoagulative State of Long Covid Disease

This study has reviewed the many roles of lumican as a biomarker of tissue pathology in health and disease. Lumican is a structure regulatory proteoglycan of collagen-rich tissues, with cell instructive properties through interactions with a number of cell surface receptors in tissue repair, thereby...

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Published inInternational journal of molecular sciences Vol. 25; no. 5; p. 2825
Main Authors Smith, Margaret M, Melrose, James
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 29.02.2024
MDPI
Subjects
anti-tumour
biomarker
Biomarkers
Blood proteins
Cell differentiation
Cell growth
Chondroitin Sulfate Proteoglycans - metabolism
Collagen
COVID-19
Development and progression
Health aspects
Humans
Inflammation
Kinases
Long COVID
Lumican
MMP inhibitor
Pathology
Post-Acute COVID-19 Syndrome
Proteoglycans
Review
tissue pathology
Type 2 diabetes
Yang Mu
MMP inhibitor
anti-tumour
lumican
biomarker
tissue pathology
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Abstract This study has reviewed the many roles of lumican as a biomarker of tissue pathology in health and disease. Lumican is a structure regulatory proteoglycan of collagen-rich tissues, with cell instructive properties through interactions with a number of cell surface receptors in tissue repair, thereby regulating cell proliferation, differentiation, inflammation and the innate and humoral immune systems to combat infection. The exponential increase in publications in the last decade dealing with lumican testify to its role as a pleiotropic biomarker regulatory protein. Recent findings show lumican has novel roles as a biomarker of the hypercoagulative state that occurs in SARS CoV-2 infections; thus, it may also prove useful in the delineation of the complex tissue changes that characterize COVID-19 disease. Lumican may be useful as a prognostic and diagnostic biomarker of long COVID disease and its sequelae.
AbstractList This study has reviewed the many roles of lumican as a biomarker of tissue pathology in health and disease. Lumican is a structure regulatory proteoglycan of collagen-rich tissues, with cell instructive properties through interactions with a number of cell surface receptors in tissue repair, thereby regulating cell proliferation, differentiation, inflammation and the innate and humoral immune systems to combat infection. The exponential increase in publications in the last decade dealing with lumican testify to its role as a pleiotropic biomarker regulatory protein. Recent findings show lumican has novel roles as a biomarker of the hypercoagulative state that occurs in SARS CoV-2 infections; thus, it may also prove useful in the delineation of the complex tissue changes that characterize COVID-19 disease. Lumican may be useful as a prognostic and diagnostic biomarker of long COVID disease and its sequelae.
Audience Academic
Author Smith, Margaret M
Melrose, James
AuthorAffiliation 2 Arthropharm Pty Ltd., Bondi Junction, NSW 2022, Australia
1 Raymond Purves Laboratory, Institute of Bone and Joint Research, Kolling Institute of Medical Research, Faculty of Health and Science, University of Sydney, Royal North Shore Hospital, St. Leonards, NSW 2065, Australia; mobsmith@sydney.edu.au
3 Graduate School of Biomedical Engineering, Faculty of Engineering, University of New South Wales, Sydney, NSW 2052, Australia
AuthorAffiliation_xml – name: 2 Arthropharm Pty Ltd., Bondi Junction, NSW 2022, Australia
– name: 3 Graduate School of Biomedical Engineering, Faculty of Engineering, University of New South Wales, Sydney, NSW 2052, Australia
– name: 1 Raymond Purves Laboratory, Institute of Bone and Joint Research, Kolling Institute of Medical Research, Faculty of Health and Science, University of Sydney, Royal North Shore Hospital, St. Leonards, NSW 2065, Australia; mobsmith@sydney.edu.au
Author_xml – sequence: 1
  givenname: Margaret M
  orcidid: 0000-0002-2020-0056
  surname: Smith
  fullname: Smith, Margaret M
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  givenname: James
  orcidid: 0000-0001-9237-0524
  surname: Melrose
  fullname: Melrose, James
  organization: Graduate School of Biomedical Engineering, Faculty of Engineering, University of New South Wales, Sydney, NSW 2052, Australia
BackLink https://www.ncbi.nlm.nih.gov/pubmed/38474072$$D View this record in MEDLINE/PubMed
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Keywords MMP inhibitor
anti-tumour
lumican
biomarker
tissue pathology
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RelatedPersons Yang Mu
RelatedPersons_xml – fullname: Yang Mu
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Snippet This study has reviewed the many roles of lumican as a biomarker of tissue pathology in health and disease. Lumican is a structure regulatory proteoglycan of...
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SubjectTerms anti-tumour
biomarker
Biomarkers
Blood proteins
Cell differentiation
Cell growth
Chondroitin Sulfate Proteoglycans - metabolism
Collagen
COVID-19
Development and progression
Health aspects
Humans
Inflammation
Kinases
Long COVID
Lumican
MMP inhibitor
Pathology
Post-Acute COVID-19 Syndrome
Proteoglycans
Review
tissue pathology
Type 2 diabetes
Yang Mu
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Title Lumican, a Multifunctional Cell Instructive Biomarker Proteoglycan Has Novel Roles as a Marker of the Hypercoagulative State of Long Covid Disease
URI https://www.ncbi.nlm.nih.gov/pubmed/38474072
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https://pubmed.ncbi.nlm.nih.gov/PMC10931941
https://doaj.org/article/27c6de288d7c4a8e923dab519ac6807d
Volume 25
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