Free Radical Oxidation in Rats in the Delayed Period after Combined Exposure to Dust and Radiation

• Published in: Bulletin of experimental biology and medicine Vol. 154; no. 6; pp. 747 - 749
• Main Authors: Tapbergenov, S. O., Zhetpisbaev, B. A., Ilderbayev, O. Z., Zhetpisbaeva, H. S., Olzhayeva, R. R., Prozor, I. I., Usenova, O. A., Ilderbayeva, G. O.
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.04.2013; Springer; Springer Nature B.V
• Subjects: Adaptation, Physiological; Adrenal Glands - metabolism; Adrenal Glands - radiation effects; Animals; Animals, Outbred Strains; Antioxidants; Asbestos - toxicity; Biomedical and Life Sciences; Biomedicine; Carcinogens - toxicity; Cell Biology; Disease Models, Animal; Dust; Free Radicals - metabolism; Humans; Internal Medicine; Laboratory Medicine; Lipid Peroxidation; Liver - metabolism; Liver - radiation effects; Lymph Nodes - metabolism; Lymph Nodes - radiation effects; Male; Malondialdehyde - metabolism; Nuclear radiation; Occupational Exposure; Organ Specificity; Oxidation-Reduction; Oxidative Stress; Pathology; Radioactive Pollutants - toxicity; Rats; Spleen - metabolism; Spleen - radiation effects; Thymus Gland - metabolism; Thymus Gland - radiation effects; combined treatment; asbestosis; free radical processes; radiation
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-013-2046-z

We studied the intensity of free radical processes in organs (liver, spleen, thymus, lymph nodes of the small intestine, and adrenal glands) and cells (lymphocytes) in the delayed period after combined exposure to a sublethal dose of γ-radiation (6 Gy) and asbestos dust particles. Combined exposure was followed by accumulation of LPO metabolites (diene conjugates and malonic dialdehyde) in homogenates of the studied organs and resulted in antioxidant defense failure in experimental animals. Ionizing radiation have a pivotal role in these processes.