Functionalisation of Electrospun Cellulose Acetate Membranes with PEDOT and PPy for Electronic Controlled Drug Release

• Published in: Nanomaterials (Basel, Switzerland) Vol. 13; no. 9; p. 1493
• Main Authors: Lago, Beatriz, Brito, Miguel, Almeida, Cristina M M, Ferreira, Isabel, Baptista, Ana Catarina
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 27.04.2023; MDPI
• Subjects: Acetic acid; Acids; Cellulose; Cellulose acetate; Cellulose acetate membranes; Coatings; Conducting polymers; controlled drug release system; Drug delivery systems; Drug dosages; Electric fields; Electrical stimuli; Electrodes; electrospinning; Hydrogels; Ibuprofen; Identification and classification; Membranes; Methods; Nonsteroidal anti-inflammatory drugs; PEDOT; Polymers; polypyrrole; Polypyrroles; Properties; Pyrrole; Raman spectroscopy; Scanning electron microscopy; Scanning microscopy; Transdermal medication; Portugal; Germany; polypyrrole; controlled drug release system; PEDOT; electrical stimuli; conducting polymers; electrospinning; cellulose acetate
• ISSN: 2079-4991; 2079-4991
• DOI: 10.3390/nano13091493

Controlled drug release via electrical stimulation from drug-impregnated fibres was studied using electrospun cellulose acetate (CA) membranes and encapsulated ibuprofen (IBU). This research outlines the influence of polypyrrole (PPy) and poly(3,4-ethylenedioxythiophene) (PEDOT)-functionalised CA membranes and their suitability for dermal electronic-controlled drug release. Micro Raman analysis confirmed polymer functionalisation of CA membranes and drug incorporation. Scanning electron microscopy (SEM) images evidenced the presence of PPy and PEDOT coatings. The kinetic of drug release was analysed, and the passive and active release was compared. In the proposed systems, the drug release is controlled by very low electrical potentials. A potential of -0.3 V applied to membranes showed the ibuprofen retention, and a positive potential of +0.3 V, +0.5 V, or +0.8 V, depending on the conductive polymer and membrane configuration, enhanced the drug release. A small adhesive patch was constructed to validate this system for cutaneous application and verified an "ON/OFF" ibuprofen release pattern from membranes.