Involvement of l-lactate in hippocampal dysfunction of type I diabetes

Hippocampal neurons play a crucial role in memory formation. Accumulating evidence raises the possibility that hippocampal sharp-wave ripples (SW-Rs) are involved in memory consolidation. Here, we examined in an animal model of diabetes and found the amplitude of SW-Rs in diabetic mice were smaller...

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Published inJournal of pharmacological sciences Vol. 141; no. 1; pp. 79 - 82
Main Authors Kobayashi, Riho, Maruoka, Junya, Norimoto, Hiroaki, Ikegaya, Yuji, Kume, Kazuhiko, Ohsawa, Masahiro
Format Journal Article
LanguageEnglish
Published Japan Elsevier 01.09.2019
Subjects
Animals
Cognitive Dysfunction - drug therapy
Cognitive Dysfunction - etiology
Diabetes Mellitus, Type 1 - complications
Diabetes Mellitus, Type 1 - psychology
Disease Models, Animal
Hippocampus - physiopathology
Injections, Intraventricular
Lactates - administration & dosage
Lactates - pharmacology
Male
Memory - physiology
Mice
Mice, Inbred ICR
Neurons - physiology
Diabetes mellitus
Sharp wave ripples (SW-Rs)
Cognitive impairment
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Summary:Hippocampal neurons play a crucial role in memory formation. Accumulating evidence raises the possibility that hippocampal sharp-wave ripples (SW-Rs) are involved in memory consolidation. Here, we examined in an animal model of diabetes and found the amplitude of SW-Rs in diabetic mice were smaller than control group and were rescued by acute application of l-lactate, a major neural energy source. The cognitive impairment in diabetic mice was alleviated by intracerebroventricular l-lactate treatment. Our results suggested that l-lactate is important for hippocampal dysfunction in diabetes.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1347-8613
1347-8648
DOI:10.1016/j.jphs.2019.09.004