Data of the quantification of the influence of DMSO concentration on the kinetic of interaction between TNFα and SPD304

• Published in: Data in brief Vol. 39; p. 107610
• Main Authors: Attia, Ghada, Mascret, Aïda, Zerrouki, Chouki, Fourati, Najla, Veitía, Maité Sylla-Iyarreta, Port, Marc
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.12.2021; Elsevier
• Subjects: Affinity; Analytical chemistry; Chemical Sciences; Data; DMSO cosolvent; Engineering Sciences; Medicinal Chemistry; Physics; SPD304; Surface acoustic wave biosensor; TNFα; SPD304; Affinity; TNFα; Surface acoustic wave biosensor; DMSO cosolvent
• ISSN: 2352-3409; 2352-3409
• DOI: 10.1016/j.dib.2021.107610

The data presented here are related to the article entitled “New contributions to the drug profile of TNFα inhibitor SPD304: affinity, selectivity ADMET considerations” published in the European Journal of pharmacology. As DMSO is usually used as a co-solvent to dissolve low aqueous soluble small molecules, such as SPD304, we have investigated the influence of its concentration on the kinetic of interaction between tumor necrosis factor α (TNF-α) and its inhibitor, SPD304. The presented data, acquired using a surface acoustic wave sensor, can be used in further biological studies to compare the kinetic of interaction between proteins/small molecules in general and TNFα/inhibitors in particular. The estimated dissociation constant can be compared to other ones to statute on the degree of affinity between a protein and a given molecule.