Dexamethasone Effects on Activation and Proliferation of Immune Memory T Cells

• Published in: Bulletin of experimental biology and medicine Vol. 155; no. 4; pp. 474 - 476
• Main Authors: Gutsol, A. A., Sokhonevich, N. A., Seledtsov, V. I., Litvinova, L. S.
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.08.2013; Springer; Springer Nature B.V
• Subjects: Adult; Antigens, CD - metabolism; Biomedical and Life Sciences; Biomedicine; Cell Biology; Cell Proliferation - drug effects; Cells, Cultured; Central nervous system depressants; Dexamethasone; Dexamethasone - pharmacology; Female; Glucocorticoids - pharmacology; Glucocorticoids - physiology; Humans; Interleukin-2 - metabolism; Interleukin-2 Receptor alpha Subunit - metabolism; Internal Medicine; Laboratory Medicine; Lymphocyte Activation - drug effects; Male; Pathology; Receptors, Transferrin - metabolism; T cells; T-Lymphocytes - drug effects; T-Lymphocytes - immunology; T-Lymphocytes - metabolism; Young Adult; dexamethasone; interleukin-2; memory T-cells; cell activation
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-013-2182-5

Dose-dependent effects of dexamethasone on activation and proliferation of donor immune memory T cells (CD45RO + ) were studied. Activation of memory T cells associated with IL-2 production and membrane expression of CD25 molecule was resistant to dexamethasone. Proliferative activity of memory T cells associated with membrane expression of CD71 molecule was highly sensitive to dexamethasone. Hence, glucocorticoid hormones can maintain the clonal balance in the lymphoid tissue without preventing realization of the immune memory mechanism.