Efficient Method for the Preparation of Carboxylic Acid Alkyl Esters or Alkyl Phenyl Ethers by a New-Type of Oxidation–Reduction Condensation Using 2,6-Dimethyl-1,4-benzoquinone and Alkoxydiphenylphosphines

A new-type of oxidation–reduction condensation proceeded smoothly to afford carboxylic acid alkyl esters or alkyl phenyl ethers in good to high yields by combined use of alkoxydiphenylphosphines (1) having primary, bulky secondary or tertiary alkoxy groups, a mild quinone-type oxidant such as 2,6-di...

Full description

Saved in:
Bibliographic Details
Published inBulletin of the Chemical Society of Japan Vol. 76; no. 8; pp. 1645 - 1667
Main Authors Shintou, Taichi, Kikuchi, Wataru, Mukaiyama, Teruaki
Format Journal Article
LanguageEnglish
Published TOKYO The Chemical Society of Japan 2003
Chemical Soc Japan
Chemical Society of Japan
Subjects
Chemistry
Chemistry, Multidisciplinary
Physical Sciences
Science & Technology
SECONDARY ALCOHOLS
REAGENT
RADICAL-ANIONS
DIETHYL AZODICARBOXYLATE
AMINO-ACIDS
MITSUNOBU REACTIONS
PHOSPHORIC ACID
ESTERIFICATION
ARYL ETHERS
ELECTRON APPORTIONMENT
Online AccessGet full text

Cover

More Information
Summary:A new-type of oxidation–reduction condensation proceeded smoothly to afford carboxylic acid alkyl esters or alkyl phenyl ethers in good to high yields by combined use of alkoxydiphenylphosphines (1) having primary, bulky secondary or tertiary alkoxy groups, a mild quinone-type oxidant such as 2,6-dimethyl-1,4-benzoquinone (DMBQ) and carboxylic acids or phenols. Generally, alkoxydiphenylphosphines were prepared easily from chlorodiphenylphosphine (2) and alcohols in the presence of pyridine, and were isolated by distillation. On the other hand, the phosphines 1 were also prepared in situ from N,N-dimethylaminodiphenylphosphine (3a) and primary or secondary alcohols while primary, bulky secondary or tertiary alkoxydiphenylphosphines were alternatively formed in situ by adding 2 to the nBuLi-treated alcohols in order to perform the above reactions by a one-pot procedure from alcohols and nucleophiles. The reaction of thus formed 1, DMBQ and carboxylic acids or phenols afforded the corresponding alkylated products, including hindered secondary and tertiary alkylated ones, in good to high yields at room temperature. In the case of using chiral secondary alcohols, the corresponding carboxylic acid alkyl esters were obtained as well in high yields with perfect inversion of stereochemistry by SN2 replacement.
ISSN:0009-2673
1348-0634
DOI:10.1246/bcsj.76.1645