METTL1 gene polymorphisms and Wilms tumor susceptibility in Chinese children: A five-center case-control study

• Published in: Chinese medical journal Vol. 136; no. 14; pp. 1750 - 1752
• Main Authors: Deng, Linqing, Hua, Ruixi, Zhang, Zhengtao, Zhu, Jinhong, Zhang, Jiao, Cheng, Jiwen, Li, Suhong, Zhou, Haixia, Liu, Guochang, He, Jing, Fu, Wen
• Format: Journal Article
• Language: English
• Published: China Lippincott Williams & Wilkins Ovid Technologies 20.07.2023; Lippincott Williams & Wilkins; Wolters Kluwer
• Subjects: Cancer; Case-Control Studies; Cell adhesion & migration; Cell cycle; Child; Confidence intervals; Correspondence; East Asian People; Families & family life; Genes; Genetic Predisposition to Disease - genetics; Genomes; Genotype & phenotype; Humans; Medical prognosis; Methyltransferases - genetics; MicroRNAs; Polymorphism, Genetic; Protein synthesis; Proteins; Transfer RNA; Tumorigenesis; Wilms Tumor - genetics; Wilms Tumor - pathology; United States > US
• ISSN: 0366-6999; 2542-5641
• DOI: 10.1097/CM9.0000000000002739

To date, the relationship between METTL1 gene polymorphisms and Wilms tumor has never been described. [...]we carried out a large case-control study to explore their relationship and the etiology of Wilms tumor. [...]the METTL1 gene not only served as a potential oncogene but also acted as a tumor suppressor. [...]it is reasonable to speculate that METTL1 may be involved in the occurrence of Wilms tumor, but we have not confirmed that METTL1 gene SNPs play a cancer-suppressing or cancer-promoting role in Wilms tumor. [...]most variants of SNPs that are associated with cancer susceptibility are always located in non-coding regulatory regions, suggesting that transcriptional regulation plays a key role in cancer susceptibility.