Environmental Pollution and Risk of Childhood Cancer: A Scoping Review of Evidence from the Last Decade

• Published in: International journal of molecular sciences Vol. 25; no. 6; p. 3284
• Main Authors: Navarrete-Meneses, María Del Pilar, Salas-Labadía, Consuelo, Gómez-Chávez, Fernando, Pérez-Vera, Patricia
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.03.2024; MDPI
• Subjects: Air Pollutants - analysis; Air pollution; Air Pollution - analysis; Air Pollution, Indoor; Alcohol; Cancer; Cancer in children; Child; childhood cancer; childhood leukemia; Electromagnetic fields; Electromagnetism; Environmental Exposure - adverse effects; Environmental Pollutants - toxicity; Environmental Pollution; Epigenetics; Female; Humans; Hydrocarbons; Investigations; Leukemia; Neoplasms - epidemiology; Neoplasms - etiology; Nervous system; Oncology, Experimental; Outdoor air quality; PCB; Pesticides; Pesticides - toxicity; Pollutants; Polychlorinated biphenyls; Pregnancy; Pregnant women; Public health; Radiation; Radiation, Background; Remission (Medicine); Retinoblastoma; Review; Risk factors; Smoking; Tobacco; Tumors; VOCs; Volatile organic compounds; Iran; California; air pollution; childhood cancer; childhood leukemia; electromagnetic fields; pesticides; environmental pollution
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms25063284

The long-term effects of environmental pollution have been of concern as several pollutants are carcinogenic, potentially inducing a variety of cancers, including childhood cancer, which is a leading cause of death around the world and, thus, is a public health issue. The present scoping review aimed to update and summarize the available literature to detect specific environmental pollutants and their association with certain types of childhood cancer. Studies published from 2013 to 2023 regarding environmental pollution and childhood cancer were retrieved from the PubMed database. A total of 174 studies were eligible for this review and were analyzed. Our search strategy brought up most of the articles that evaluated air pollution (29%) and pesticides (28%). Indoor exposure to chemicals (11%), alcohol and tobacco use during pregnancy (16%), electromagnetic fields (12%), and radon (4%) were the subjects of less research. We found a particularly high percentage of positive associations between prenatal and postnatal exposure to indoor (84%) and outdoor (79%) air pollution, as well as to pesticides (82%), and childhood cancer. Positive associations were found between leukemia and pesticides and air pollution (33% and 27%); CNS tumors and neuroblastoma and pesticides (53% and 43%); and Wilms tumor and other rare cancers were found in association with air pollution (50%). Indoor air pollution was mostly reported in studies assessing several types of cancer (26%). Further studies are needed to investigate the mechanisms underlying the potential associations between indoor/outdoor air pollution and pesticide exposure with childhood cancer risk as more preventable measures could be taken.