Iron-Dependent Synthesis of Hemolysins by Staphylococcus aureus

We studied the effect of Fe 2+ on hemolysin synthesis by Staphylococcus aureus . Hemolytic activity of staphylococci was shown to be iron-dependent. Addition of Fe 2+ to the nutrient medium induced the synthesis of α-hemolysin by staphylococci. Increasing the concentration of Fe 2+ was followed by a...

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Published inBulletin of experimental biology and medicine Vol. 153; no. 1; pp. 41 - 43
Main Authors Leonov, V. V., Kosterina, V. V., Varnitsina, V. V., Timokhina, T. Kh, Kurlovich, N. A.
Format Journal Article
LanguageEnglish
Published Boston Springer US 01.05.2012
Springer
Springer Nature B.V
Subjects
Biomedical and Life Sciences
Biomedicine
Cell Biology
Cells, Cultured
Cholera toxin
Development and progression
Hemoglobin
Hemolysin Proteins - metabolism
Hemolysins
Hemolysis - physiology
Hemolysis and hemolysins
Humans
Infection
Internal Medicine
Iron
Iron - metabolism
Laboratory Medicine
Nutrients
Pathology
Staphylococcus aureus
Staphylococcus aureus - metabolism
hemolysins
iron
hemolytic activity
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Summary:We studied the effect of Fe 2+ on hemolysin synthesis by Staphylococcus aureus . Hemolytic activity of staphylococci was shown to be iron-dependent. Addition of Fe 2+ to the nutrient medium induced the synthesis of α-hemolysin by staphylococci. Increasing the concentration of Fe 2+ was followed by an increase in hemolytic activity of staphylococci. Inducible synthesis of α-hemolysin probably serves as an important pathogenetic factor in the development of staphylococcal infection in patients with excessive iron accumulation in the body.
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ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-012-1645-4