Dilated Cardiomyopathy Concepts Derived From Gene Deficient and Transgenic Animal Models

• Published in: Circulation Journal Vol. 66; no. 3; pp. 219 - 224
• Main Author: Ross, John, Jr
• Format: Journal Article
• Language: English
• Published: Kyoto The Japanese Circulation Society 2002; Japanese Circulation Society
• Subjects: Animals; Animals, Genetically Modified; Biological and medical sciences; Cardiac failure; Cardiology. Vascular system; Cardiomyopathy, Dilated - etiology; Cardiomyopathy, Dilated - genetics; Cardiomyopathy, Dilated - therapy; Disease Models, Animal; Double transgenesis; Extrasarcomeric proteins; Gene mutations; Heart; Humans; In vivo somatic gene transfer; Intrasarcomeric proteins; Medical sciences; Mice; Mice, Knockout; Mutation; Myocarditis. Cardiomyopathies; Recombination; β-adrenergic signaling pathway; Heart failure; Recombination; Pathogenesis; Rodentia; Transgenic animal; Cardiovascular disease; Myocardial disease; Genetic determinism; Protein; Vertebrata; Mammalia; Congestive hypertrophic cardiomyopathy; Gene; Mouse; Heart disease; Animal; Mutation; Sarcomere
• ISSN: 1346-9843; 1347-4820
• DOI: 10.1253/circj.66.219

Genetic forms of human dilated cardiomyopathy (DCM) are briefly discussed, and a variety of animal models of genetic DCM are presented, some of which are caused by the gene mutations that also cause DCM in humans. The forms of DCM related to mutations or deletion of genes coding for extrasarcomeric or intrasarcomeric proteins, as well as to overexpression or knockout of genes in the β-adrenergic signaling pathway, are included. Finally, novel approaches to treatment in experimental animal models are discussed, including double transgenesis and newer recombination methods, as well as in vivo somatic gene transfer which, based on initial experiments in animals, seems likely to find eventual application in human cardiac failure. (Circ J 2002; 66: 219 -224)