Herquline A, produced by Penicillium herquei FKI-7215, exhibits anti-influenza virus properties

In the course of screening for new anti-influenza virus antibiotics, we isolated herquline A from a culture broth of the fungus, Penicillium herquei FKI-7215. Herquline A inhibited replication of influenza virus A/PR/8/34 strain in a dose-dependent manner without exhibiting cytotoxicity against seve...

Full description

Saved in:
Bibliographic Details
Published inBioscience, biotechnology, and biochemistry Vol. 81; no. 1; pp. 59 - 62
Main Authors Chiba, Takuya, Asami, Yukihiro, Suga, Takuya, Watanabe, Yoshihiro, Nagai, Takayuki, Momose, Fumitaka, Nonaka, Kenichi, Iwatsuki, Masato, Yamada, Haruki, Ōmura, Satoshi, Shiomi, Kazuro
Format Journal Article
LanguageEnglish
Published England Taylor & Francis 01.01.2017
Subjects
A/PR/8/34 strain
Alkaloids - biosynthesis
Alkaloids - chemistry
Alkaloids - pharmacology
Alkaloids - toxicity
Antiviral Agents - chemistry
Antiviral Agents - metabolism
Antiviral Agents - pharmacology
Antiviral Agents - toxicity
Cell Line
Dose-Response Relationship, Drug
Drug Evaluation, Preclinical
herquline A
Humans
influenza virus
Orthomyxoviridae - drug effects
Orthomyxoviridae - physiology
Penicillium - metabolism
Penicillium herquei
Virus Replication - drug effects
influenza virus
A/PR/8/34 strain
Penicillium herquei
herquline A
Online AccessGet full text

Cover

More Information
Summary:In the course of screening for new anti-influenza virus antibiotics, we isolated herquline A from a culture broth of the fungus, Penicillium herquei FKI-7215. Herquline A inhibited replication of influenza virus A/PR/8/34 strain in a dose-dependent manner without exhibiting cytotoxicity against several human cell lines. It did not inhibit the viral neuraminidase.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0916-8451
1347-6947
DOI:10.1080/09168451.2016.1162084