Graphene-based magnetic nanoparticles for theranostics: an overview for their potential in clinical application

• Published in: Nanomaterials (Basel, Switzerland) Vol. 11; no. 5; pp. 1073(1) - 1073(16)
• Main Authors: Lage, Teresa Cristina Carqueijó, Rodrigues, Raquel Oliveira, Catarino, Susana Oliveira, Gallo, Juan, Bañobre-López, Manuel, Minas, Graça
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI 22.04.2021; MDPI AG
• Subjects: Biocompatibility; Biotecnologia Médica; Carbon; Carrier mobility; Chemical vapor deposition; Ciências Médicas; Current carriers; Graphene; graphene-based nanomaterials; Graphite; Hyperthermia; Magnetic nanoparticles; Magnetic properties; Magnetic resonance imaging; Nanomaterials; Nanoparticles; Nanotechnology; Particle size; Precision medicine; Quantum dots; Review; Saúde de qualidade; Science & Technology; Synergistic effect; Theranostic; Thermal stability; graphene-based nanomaterials; magnetic nanoparticles; theranostic; graphene
• ISSN: 2079-4991; 2079-4991
• DOI: 10.3390/nano11051073

The combination of diagnostics and therapy (theranostic) is one of the most complex, yet promising strategies envisioned for nanoengineered multifunctional systems in nanomedicine. From the various multimodal nanosystems proposed, a number of works have established the potential of Graphene-based Magnetic Nanoparticles (GbMNPs) as theranostic platforms. This magnetic nanosystem combines the excellent magnetic performance of magnetic nanoparticles with the unique properties of graphene-based materials, such as large surface area for functionalization, high charge carrier mobility and high chemical and thermal stability. This hybrid nanosystems aims toward a synergistic theranostic effect. Here, we focus on the most recent developments in GbMNPs for theranostic applications. Particular attention is given to the synergistic effect of these composites, as well as to the limitations and possible future directions towards a potential clinical application. This work is the result of the project NORTE-01-0145-FEDER-029394, RTChip4Theranostics, and was supported by Programa Operacional Regional do Norte-Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement through the European Regional Development Fund (FEDER) and by Fundação para a Ciência e Tecnologia (FCT), IP, project reference PTDC/EMD-EMD/29394/2017. The authors also acknowledge the partial financial support by the projects UID/EEA/04436/2020 and by the project NORTE-01-0145-FEDER- 030171.