Epidemiological studies of migration and environmental risk factors in the inflammatory bowel diseases

Inflammatory bowel diseases(IBD)are idiopathic chronic diseases of the gastrointestinal tract well known to be associated with both genetic and environmental risk factors.Permissive genotypes may manifest into clinical phenotypes under certain environmental influences and these may be best studied f...

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Published inWorld journal of gastroenterology : WJG Vol. 20; no. 5; pp. 1238 - 1247
Main Authors Ko, Yanna, Butcher, Rhys, Leong, Rupert W
Format Journal Article
LanguageEnglish
Published United States Baishideng Publishing Group Co., Limited 07.02.2014
Subjects
bowel
Colitis, Ulcerative - diagnosis
Colitis, Ulcerative - epidemiology
Colitis, Ulcerative - genetics
Crohn Disease - diagnosis
Crohn Disease - epidemiology
Crohn Disease - genetics
Crohn’s
dis-ease
disease
Emigrants and Immigrants
Emigration and Immigration - trends
Gene-Environment Interaction
Genetic Predisposition to Disease
Humans
Incidence
Inflammatory
Prevalence
Racial Groups - genetics
Risk Factors
Time Factors
Topic Highlight
Ulcera
Inflammatory bowel disease
Risk factor
Hygiene hypothesis
Environment
Epidemiology
Crohn’s disease
Ulcerative colitis
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Summary:Inflammatory bowel diseases(IBD)are idiopathic chronic diseases of the gastrointestinal tract well known to be associated with both genetic and environmental risk factors.Permissive genotypes may manifest into clinical phenotypes under certain environmental influences and these may be best studied from migratory studies.Exploring differences between first and second generation migrants may further highlight the contribution of environmental factors towards the development of IBD.There are few opportunities that have been offered so far.We aim to review the available migration studies on IBD,evaluate the known environmental factors associated with IBD,and explore modern migration patterns to identify new opportunities and candidate migrant groups in IBD migration research.
Bibliography:Yanna Ko;Rhys Butcher;Rupert W Leong;Concord Hospital, Gastroenterology and Liver Services and The University of New South Wales
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Author contributions: Ko Y contributed to this work, performed the literature review and the literature review, and analysed the data; Leong RW designed the research; Ko Y, Butcher R and Leong RW wrote the paper.
Correspondence to: Rupert W Leong, MBBS, MD, FRACP, AGAF, Associate Professor, Concord Hospital, Gastroenterology and Liver Services and The University of New South Wales, Level 1 West Hospital Rd, Concord, Sydney NSW 2139, Australia. rupertleong@outlook.com
Telephone: +61-2-97676111 Fax: +61-2-97676767
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v20.i5.1238