GC–MS Analysis of Bio-active Molecules Derived from Paracoccus pantotrophus FMR19 and the Antimicrobial Activity Against Bacterial Pathogens and MDROs

• Published in: Indian journal of microbiology Vol. 56; no. 4; pp. 426 - 432
• Main Authors: Faridha Begum, I., Mohankumar, R., Jeevan, M., Ramani, K.
• Format: Journal Article
• Language: English
• Published: New Delhi Springer India 01.12.2016; Springer Nature B.V
• Subjects: Antibiotics; Antimicrobial agents; Aromatic hydrocarbons; Bioactive compounds; Biomedical and Life Sciences; Carbon; Fatty acids; Life Sciences; Medical Microbiology; Metabolites; Microbiology; Microorganisms; Multidrug resistant organisms; Original; Original Article; Paracoccus pantotrophus; Pathogens; Salmonella; Staphylococcus aureus; Tamil Nadu India; India; Bioactive compound; Antibacterial activity; GC–MS; Rumen bacteria; Multi-drug resistant organisms; FMR19; Paracoccus pantotrophus FMR19
• ISSN: 0046-8991; 0973-7715
• DOI: 10.1007/s12088-016-0609-1

The present investigation is focused on the study of chemical composition of a bioactive compound derived from a rumen isolate Paracoccus pantotrophus FMR19 using GC–MS and to find out the antibacterial activity of the extracted crude bioactive compounds against multidrug resistant organisms (MDROs) and other clinical pathogens. GC–MS analysis revealed that P. pantotrophus FMR19 produced eight major compounds that have been reported to exhibit antimicrobial property. The main components identified from hexane fraction are long chain alkanes, fatty alcohols, fatty acid methyl ester and aromatic hydrocarbons. These molecules are not only active against clinical pathogens such as Salmonella sp. and Proteus sp. and also effective against MDROs such as Metallo β lactamase and Pan drug resistant bacterial strains and Methicillin resistant Staphylococcus aureus .