Expression of inflammation-mediated cluster of genes as a new marker of canine mammary malignancy

• Published in: Veterinary research communications Vol. 37; no. 2; pp. 123 - 131
• Main Authors: Pawłowski, K. M., Homa, A., Bulkowska, M., Majchrzak, K., Motyl, T., Król, M.
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.06.2013; Springer Nature B.V
• Subjects: Animals; Biomarkers, Tumor - biosynthesis; Biomarkers, Tumor - genetics; Biomedical and Life Sciences; Dog Diseases - diagnosis; Dog Diseases - genetics; Dog Diseases - metabolism; Dog Diseases - pathology; Dogs; Female; Gene Expression Regulation, Neoplastic; Immunohistochemistry - veterinary; Inflammation - diagnosis; Inflammation - genetics; Inflammation - pathology; Inflammation - veterinary; Life Sciences; Mammary Neoplasms, Animal - diagnosis; Mammary Neoplasms, Animal - genetics; Mammary Neoplasms, Animal - metabolism; Mammary Neoplasms, Animal - pathology; Neoplasm Grading; Oligonucleotide Array Sequence Analysis - veterinary; Original; Original Article; Reverse Transcriptase Polymerase Chain Reaction - veterinary; RNA, Neoplasm - chemistry; RNA, Neoplasm - genetics; Veterinary Medicine/Veterinary Science; Zoology; Myeloid cells infiltration; Malignancy markers; Real-time qPCR; Microarrays; Canine mammary cancer
• ISSN: 0165-7380; 1573-7446
• DOI: 10.1007/s11259-013-9554-1

Because canine mammary tumours constitute a serious clinical problem and there are no good prognostic markers (only histopathological variables are used), the aim of the presented study was to find new malignancy markers as well as to identify intracellular pathways and biological processes characteristic for canine mammary malignancy. We compared gene expression of the most malignant mammary tumours (poorly differentiated cancers of the 3rd grade of malignancy) with less malignant tumours (well differentiated cancers of the 1st grade of malignancy). The results of our study indicated that in dogs the number of tumour-infiltrating myeloid cells or expression of myeloid-specific antigens by cancer cells is related to the cancer progression and may constitute a new marker of malignancy, however further studies in this field are required.